All Phenotypes Hprt1<tm4(CAG-Tbx18*,-Venus)Akis> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}
targeted mutation 4, Andreas Kispert
MGI:5576943

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI	MGI:5576973
cn2	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576974

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:210076 )

• epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

• mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

• sinus horn defects

heart hypoplasia ( J:210076 )

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23