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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam17tm1.1Wesh
targeted mutation 1.1, Wei Shi
MGI:5571391
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * C57BL/6 * FVB/N MGI:5571468
cn2
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5571466
cn3
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Twist2tm1.1(cre)Dor/Twist2+ 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:5571469
cn4
 		Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+ 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:5571470


Genotype
MGI:5571468
cn1
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• doxycycline-treated mice exhibit normal neonatal survival

respiratory system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice
abnormal lung saccule morphology ( J:210193 )
• at E18.5, doxycycline-treated mice exhibit reduced terminal sacs and thickened surrounding mesenchyme in the peripheral lung compared with control mice
• larger but fewer sacs at P1 in doxycycline-treated mice
• however, morphology at P14 and P30 is normal
thick lung-associated mesenchyme ( J:210193 )
• at E18.5 in doxycycline-treated mice
abnormal lung epithelium morphology ( J:210193 )
• impaired epithelial cell differentiation in doxycycline-treated mice

cellular
decreased cell proliferation ( J:210193 )
• at P1, but not P30, in the lungs of doxycycline-treated mice

cardiovascular system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice




Genotype
MGI:5571466
cn2
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (62 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• mice exhibit normal neonatal survival

cardiovascular system
abnormal myocardium layer morphology ( J:210193 )
• reduced myocardial compaction at E18.5
thin myocardium ( J:210193 )
• at E18.5
enlarged heart ( J:210193 )
• at E18.5

muscle
abnormal myocardium layer morphology ( J:210193 )
• reduced myocardial compaction at E18.5
thin myocardium ( J:210193 )
• at E18.5

growth/size/body
enlarged heart ( J:210193 )
• at E18.5




Genotype
MGI:5571469
cn3
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (62 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:210193 )
N
• mice exhibit normal lung development




Genotype
MGI:5571470
cn4
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (5 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• doxycycline-treated mice exhibit normal neonatal survival

respiratory system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice
abnormal lung saccule morphology ( J:210193 )
• doxycycline-treated mice exhibit enlarged airspaces with fewer number of saccules and reduced epithelial cell differentiation compared with control mice

cellular
decreased cell proliferation ( J:210193 )
• in the lungs of doxycycline-treated mice

cardiovascular system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory