About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir10atm1.1Ahl
targeted mutation 1.1, Anders Lund
MGI:5567937
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir10atm1.1Ahl/Mir10atm1.1Ahl B6.129(C)-Mir10atm1.1Ahl MGI:5567979
cx2
 		ApcMin/Apc+
Mir10atm1.1Ahl/Mir10atm1.1Ahl 		B6.Cg-Mir10atm1.1Ahl Apcmin MGI:5567980


Genotype
MGI:5567979
hm1
Allelic
Composition		 Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic
Background		 B6.129(C)-Mir10atm1.1Ahl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir10atm1.1Ahl mutation (1 available); any Mir10a mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:205135 )
• mice are exhibit birth in Mendelian ratios, normal growth and development, normal survival and normal susceptibility to spontaneous tumor development




Genotype
MGI:5567980
cx2
Allelic
Composition		 ApcMin/Apc+
Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic
Background		 B6.Cg-Mir10atm1.1Ahl Apcmin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (151 available)
Mir10atm1.1Ahl mutation (1 available); any Mir10a mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Enhanced intestinal tumorigenesis in ApcMin/Apc+ Mir10atm1.1Ahl/Mir10atm1.1Ahl mice

neoplasm
increased gastrointestinal tumor incidence ( J:205135 )
• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
increased intestinal adenoma incidence ( J:205135 )
• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:205135 )
• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
increased intestinal adenoma incidence ( J:205135 )
• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory