Analysis Tools
normal phenotype
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• mice are exhibit birth in Mendelian ratios, normal growth and development, normal survival and normal susceptibility to spontaneous tumor development
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Allele Symbol Allele Name Allele ID |
Mir10atm1.1Ahl targeted mutation 1.1, Anders Lund MGI:5567937 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are exhibit birth in Mendelian ratios, normal growth and development, normal survival and normal susceptibility to spontaneous tumor development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Enhanced intestinal tumorigenesis in ApcMin/Apc+ Mir10atm1.1Ahl/Mir10atm1.1Ahl mice
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• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
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• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes
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• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
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• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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