Mir10a^tm1.1Ahl
Targeted Allele Detail

Summary

• Symbol: Mir10a^tm1.1Ahl
• Name: microRNA 10a; targeted mutation 1.1, Anders Lund
• MGI ID: MGI:5567937
• Gene: Mir10a Location: Chr11:96207991-96208100 bp, + strand Genetic Position: Chr11, 59.83 cM
• Alliance: Mir10a^tm1.1Ahl page

Enhanced intestinal tumorigenesis in Apc^Min/Apc⁺ Mir10a^tm1.1Ahl/Mir10a^tm1.1Ahl mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205135
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: A floxed neomycin resistance cassette replaced the central 70 bp. Cre-mediated recombination removed the selection cassette. (J:205135)

Generation of the Mir10a^tm1.1Ahl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir10a Mutation: 2 strains or lines available

References

• Original: J:205135 Stadthagen G, et al., Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet. 2013 Oct;9(10):e1003913
• All: 1 reference(s)