Analysis Tools
immune system
| N |
• regulatory T cells exhibit normal suppressive functions and stability
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• severe
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Allele Symbol Allele Name Allele ID |
Itchtm1.1Alta targeted mutation 1.1, Alexander Tarakhovsky MGI:5563090 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• regulatory T cells exhibit normal suppressive functions and stability
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• severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• from 6 weeks of age
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| N |
• mice exhibit normal response to experimental autoimmune encephalomyelitis
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• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
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• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
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• slightly decreased proportion in the spleen
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• in splenic red pulp
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• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
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• absolute numbers
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• absolute numbers
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• slightly
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• modestly
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• ovalbumin-specific IgE in ovalbumin-treated mice
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• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
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• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
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• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells
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• from 6 weeks of age, mice exhibit larger size and cellularity of peripheral lymphoid organs compared with wild-type mice
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• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
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• from anti-CD3-stimulated splenocytes
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• from CD4+ T cells in the lungs
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• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
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• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
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• massive infiltration in the lungs, stomach, skin and liver
• however, no lesions are observed in the kidney and colon
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• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid
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• severe at 16 weeks
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• severe at 16 weeks
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• from 6 weeks of age
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• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid
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• from 6 weeks of age
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• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells
|
|
• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
|
|
• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
|
|
• slightly decreased proportion in the spleen
|
|
• in splenic red pulp
|
|
• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
|
|
• absolute numbers
|
|
• absolute numbers
|
|
• slightly
|
|
• modestly
|
|
• ovalbumin-specific IgE in ovalbumin-treated mice
|
|
• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
|
|
• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
|
|
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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