All Phenotypes Slc16a1<tm2.1Lupel> MGI Mouse

growth/size/body region phenotype ( J:205481 )

N	• similar rate of body weight gain under normal chow diet comparing to controls

decreased body length ( J:205481 )

• significant decrease

decreased susceptibility to diet-induced obesity ( J:205481 )

• on a high fat diet

abnormal intestinal absorption ( J:205481 )

• lower

decreased white adipose tissue amount ( J:205481 )

• significantly less subcutaneous and perigonadal WAT in mice after 11 months on a high fat diet

• smaller adipocytes in subcutaneous WAT after 11 months on a high fat diet

decreased percent body fat/body weight ( J:205481 )

• slight but significant decrease in mice on a normal chow or high fat diet for 2 and 9 months comparing to wild-type

decreased liver weight ( J:205481 )

• 40% lighter than wild-type after being on high fat diet for 11 months

decreased susceptibility to diet-induced hepatic steatosis ( J:205481 )

• appear completely normal after 11 months on a high fat diet

decreased food intake ( J:205481 )

• significant decrease in high fat diet intake in the first two weeks and level remains lower than wild-type thereafter

• lower cumulative food intake in 11 months on high fat diet

• intake on a normal chow diet is similar to controls

decreased susceptibility to diet-induced obesity ( J:205481 )

• on a high fat diet

abnormal circulating hormone level ( J:205481 )

• higher lactate levels in mice on a normal chow diet

decreased circulating insulin level ( J:205481 )

• in mice on a high fat diet but not when on a normal chow diet compared to diet matched controls

decreased circulating leptin level ( J:205481 )

• in mice on a high fat diet but not when on a normal chow diet compared to diet matched controls

decreased circulating triglyceride level ( J:205481 )

• on a normal chow diet

decreased circulating alanine transaminase level ( J:205481 )

• in mice on a high fat diet but not when on a normal chow diet compared to diet matched controls

increased carbon dioxide production ( J:205481 )

• 15% increase during daytime in mice on high fat diet for 9 weeks comparing to wild-type

• however, carbon dioxide production is similar to controls in mice on a normal chow diet

increased oxygen consumption ( J:205481 )

• 15% increase during daytime in mice on high fat diet for 9 weeks comparing to wild-type

• however, oxygen consumption is similar to controls in mice on a normal chow diet

increased respiratory quotient ( J:205481 )

• very small but significant increase during nighttime in mice on a high fat diet while no difference is detected during daytime or in mice on normal chow

improved glucose tolerance ( J:205481 )

• in animals on a high fat diet but normal glucose tolerance on a normal chow diet

increased insulin sensitivity ( J:205481 )

• in mice on a high fat diet for 8 weeks and 4 months comparing to wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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