Slc16a1^tm2.1Lupel
Targeted Allele Detail

Summary

• Symbol: Slc16a1^tm2.1Lupel
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 1; targeted mutation 2.1, Luc Pellerin
• MGI ID: MGI:5559460
• Synonyms: Mct1^LacZ, Slc16a1^tm1.1Geno
• Gene: Slc16a1 Location: Chr3:104545984-104565778 bp, + strand Genetic Position: Chr3, 45.7 cM
• Alliance: Slc16a1^tm2.1Lupel page

Slc16a1^tm2.1Lupel/Slc16a1⁺ mice exhibit decreased susceptibility to diet-induced obesity

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205481
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: An in frame insertion of a lacZ/neo cassette in exon 1 replaced a 640 bp segment following the endogenous start codon. Quantitative RT-PCR and western blot analysis detected reduced mRNA and protein expression in multiple tissues in heterozygous mice. LacZ expression was detected in the brain, heart and soleus muscle of heterozygous mice. (J:205481)

Generation of the Slc16a1^tm2.1Lupel allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a1 Mutation: 20 strains or lines available

References

• Original: J:205481 Lengacher S, et al., Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PLoS One. 2013;8(12):e82505
• All: 4 reference(s)