Phenotypes associated with this allele

• Allele Symbol: Tg(Defa6-icre)1Rsb
• Allele Name: transgene insertion 1, Richard S Blumberg
• Allele ID: MGI:5559374
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Defa6-icre)1Rsb/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5559515
cn2	Atg7^tm1Tchi/Atg7^tm1Tchi Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Defa6-icre)1Rsb/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5559516
cn3	Atg16l1^tm1c(EUCOMM)Wtsi/Atg16l1^tm1c(EUCOMM)Wtsi Tg(Defa6-icre)1Rsb/0	involves: C57BL/6	MGI:7564131

Genotype
MGI:5559515

cn1

• Allelic Composition: Xbp1^tm2Glm/Xbp1^tm2Glm; Tg(Defa6-icre)1Rsb/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small intestinal inflammation ( J:206084 )

• >75% of animals develop spontaneous enteritis with Xbp1 deletion in Paneth cells, having features similar to mice with Xbp1 deletion in IECs (intestinal epithelial cells)

digestive/alimentary system

abnormal Paneth cell morphology ( J:206084 )

• defects in granule morphology are observed

• increased cell death in crypts is observed compare to Xbp1 deletion in IECs (intestinal epithelial cells)

small intestinal inflammation ( J:206084 )

• >75% of animals develop spontaneous enteritis with Xbp1 deletion in Paneth cells, having features similar to mice with Xbp1 deletion in IECs (intestinal epithelial cells)

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:206084 )

• defects in granule morphology are observed

• increased cell death in crypts is observed compare to Xbp1 deletion in IECs (intestinal epithelial cells)

cellular

abnormal autophagy ( J:206084 )

• autophagy is induced in enterocytes in Paneth cells

homeostasis/metabolism

abnormal autophagy ( J:206084 )

• autophagy is induced in enterocytes in Paneth cells

Genotype
MGI:5559516

cn2

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Xbp1^tm2Glm/Xbp1^tm2Glm; Tg(Defa6-icre)1Rsb/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

immune system

small intestinal inflammation ( J:206084 )

• mice show transmural inflammation as early as 8 weeks of age

digestive/alimentary system

small intestinal inflammation ( J:206084 )

• mice show transmural inflammation as early as 8 weeks of age

Genotype
MGI:7564131

cn3

• Allelic Composition: Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi}; Tg(Defa6-icre)1Rsb/0
• Genetic Background: involves: C57BL/6

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus

digestive/alimentary system

abnormal intestine physiology ( J:340266 )

• in culture intestinal organoids show impaired growth and increased susceptibility to TNF-induced death

increased susceptibility to induced colitis ( J:340266 )

• following 5% DSS treatment mice show increased shortening of the colon and increased colonic inflammation

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus

immune system

increased susceptibility to induced colitis ( J:340266 )

• following 5% DSS treatment mice show increased shortening of the colon and increased colonic inflammation

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus