About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meiobtm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5559212
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Meiobtm1.1Ics/Meiobtm1.1Ics involves: C57BL/6NTac MGI:5559215


Genotype
MGI:5559215
hm1
Allelic
Composition		 Meiobtm1.1Ics/Meiobtm1.1Ics
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meiobtm1.1Ics mutation (0 available); any Meiob mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced size of testes and ovaries in Meiobtm1.1Ics/Meiobtm1.1Ics mice

reproductive system
decreased oocyte number ( J:203426 )
• starting at P3
absent oocytes ( J:203426 )
• at P10
increased male germ cell apoptosis ( J:203426 )
• increased apoptosis from P10 in testes
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
small testis ( J:203426 )
• 3.8 times
abnormal meiosis ( J:203426 )
• spermatocytes and oocytes exhibit impaired homologous synapsis, double-strand break repair and meiotic homologous recombination unlike wild-type cells
arrest of spermatogenesis ( J:203426 )
• at P10, no stage beyond primary spermatocyte is observed unlike in wild-type mice

cellular
decreased oocyte number ( J:203426 )
• starting at P3
absent oocytes ( J:203426 )
• at P10
increased male germ cell apoptosis ( J:203426 )
• increased apoptosis from P10 in testes
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
abnormal double-strand DNA break repair ( J:203426 )
• impaired double-strand break repair during meiosis in spermatocytes and oocytes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:203426 )
• impaired double-strand break repair during meiosis in spermatocytes and oocytes

endocrine/exocrine glands
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
small testis ( J:203426 )
• 3.8 times




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory