Analysis Tools
mortality/aging
| N |
• Background Sensitivity: mice on a congenic C57BL/6 background are born in Mendelian ratio unlike mice on a mixed background
|
 |
• most female mice die during parturition, in spite of oxygen administration
|
reproductive system
|
|
• most mice carry to term but cannot give birth
|
behavior/neurological
| N |
• mice exhibit normal locomotor activity in an open field and behavior in a tail suspension test
|
|
• mice spend more time exploring objects compared with wild-type mice
• however, novel object recognition is normal
|
|
• mice exhibit reduced passive avoidance compared with wild-type mice
|
|
• in an elevated zero maze, mice spend more time in the open area compared with wild-type mice
|
|
|
• impaired milk letdown in female mice that give birth
|
|
• in response to pulse-alone trials
• however, prepulse induced inhibition is normal
|
|
• on a rotarod and in a wire hang test
|
|
|
• impaired pup rearing in female mice that give birth
|
|
|
• impaired nesting in female mice that give birth
|
nervous system
| N |
• mice exhibit normal prepulse inhibition
|
|
• increased basal prolactin and growth hormone secretion
• however, stimulated levels are normal
|
acromegaly
(
J:206512
)
|
• somatotrophs exhibit elevated basal secretion of growth hormone compared with wild-type mice
• however, cells exhibit normal synthesis and storage of growth hormone and stimulated secretion is normal
|
|
• more open, less well organized than in wild-type mice
• disturbed nerve terminals and junctional folds in muscle cells
|
growth/size/body
|
|
• in female, but not male, mice
|
|
|
• in female, but not male, mice
|
 |
• in male mice
• however, female mice grow at the same rate as wild-type mice
|
endocrine/exocrine glands
|
|
• impaired milk letdown in female mice that give birth
|
|
• increased basal prolactin and growth hormone secretion
• however, stimulated levels are normal
|
acromegaly
(
J:206512
)
|
• somatotrophs exhibit elevated basal secretion of growth hormone compared with wild-type mice
• however, cells exhibit normal synthesis and storage of growth hormone and stimulated secretion is normal
|
muscle
|
• increased sarcomeric length in diaphragm muscle due to an increase in I-band length
• however, A-band length is normal
|
|
• increased I-band length in diaphragm muscle
|
|
• decreased Z-line thickness
|
cardiovascular system
| N |
• mice exhibit normal blood pressure
|
homeostasis/metabolism
| N |
• mice exhibit normal basal and stimulated corticosterone levels
|
integument
|
|
• impaired milk letdown in female mice that give birth
|
