Kalrn^tm2.1Npl
Targeted Allele Detail

Summary

• Symbol: Kalrn^tm2.1Npl
• Name: kalirin, RhoGEF kinase; targeted mutation 2.1, Neuropeptide Laboratory
• MGI ID: MGI:5551305
• Synonyms: KalSR^KO
• Gene: Kalrn Location: Chr16:33789443-34393647 bp, - strand Genetic Position: Chr16, 24.27 cM
• Alliance: Kalrn^tm2.1Npl page

Neuromuscular junctions are abnormal in Kalrn^tm2.1Npl/Kalrn^tm2.1Npl mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 13, an exon in the spectrin repeat region (KalSR), was floxed. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 13. Western blot analysis confirmed the loss of isoforms Kalirin7, 9 and 12 and deltaKalirin7 in the adult cortex. (J:206512)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kalrn Mutation: 170 strains or lines available

References

• Original: J:206512 Mandela P, et al., Kalrn plays key roles within and outside of the nervous system. BMC Neurosci. 2012;13:136
• All: 6 reference(s)