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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Nanog-cre)#Vlcg
transgene insertion, Velocigene
MGI:5545911
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		NipblGt(EUCE313f02)1.1Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1 MGI:7492239
cn2
 		NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1 MGI:7492240
cn3
 		Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546222
cn4
 		Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546213
cn5
 		Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546242
cn6
 		Droshatm2.1Vlcg/Droshatm3Vlcg
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546235
cn7
 		Dll4tm2.1Vlcg/Dll4+
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546216


Genotype
MGI:7492239
cn1
Allelic
Composition		 NipblGt(EUCE313f02)1.1Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.1Hmgu mutation (0 available); any Nipbl mutation (124 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atrial septal defect ( J:236978 )
• large defects in 33% of hearts at E17.5




Genotype
MGI:7492240
cn2
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
N
• hearts lack atrial septal defects and are indistinguishable from wild-type




Genotype
MGI:5546222
cn3
Allelic
Composition		 Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11tm1.1Vlcg mutation (0 available); any Gdf11 mutation (11 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:200671 )
• authors state that mice phenocopy Gdf11tm1Sjl homozygotes

limbs/digits/tail
short tail ( J:200671 )
• authors state that mice phenocopy Gdf11tm1Sjl homozygotes

digestive/alimentary system
cleft palate ( J:200671 )
• authors state that mice phenocopy Gdf11tm1Sjl homozygotes

growth/size/body
cleft palate ( J:200671 )
• authors state that mice phenocopy Gdf11tm1Sjl homozygotes




Genotype
MGI:5546213
cn4
Allelic
Composition		 Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1.1Vlcg mutation (0 available); any Dicer1 mutation (94 available)
Dicer1tm2.1Vlcg mutation (0 available); any Dicer1 mutation (94 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:200671 )
• authors state that mice resemble Dicer1tm1Ghan

embryo
abnormal embryo development ( J:200671 )
• authors state that mice resemble Dicer1tm1Ghan




Genotype
MGI:5546242
cn5
Allelic
Composition		 Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sosttm1(KOMP)Vlcg mutation (1 available); any Sost mutation (34 available)
Sosttm2.1Vlcg mutation (0 available); any Sost mutation (34 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton




Genotype
MGI:5546235
cn6
Allelic
Composition		 Droshatm2.1Vlcg/Droshatm3Vlcg
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm2.1Vlcg mutation (0 available); any Drosha mutation (96 available)
Droshatm3Vlcg mutation (0 available); any Drosha mutation (96 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5546216
cn7
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4+
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:200671 )
• severe as in Dll4tm1Nwg heterozygotes

embryo
abnormal embryo development ( J:200671 )
• authors state that mice phenocopy Dll4tm1Nwg heterozygotes




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory