All Phenotypes Tg(Nanog-cre)#Vlcg MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Nanog-cre)#Vlcg
transgene insertion, Velocigene
MGI:5545911

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nipbl^{Gt(EUCE313f02)1.1Hmgu}/Nipbl⁺ Tg(Nanog-cre)#Vlcg/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1	MGI:7492239
cn2	Nipbl^{Gt(EUCE313f02)Hmgu}/Nipbl⁺ Tg(Nanog-cre)#Vlcg/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1	MGI:7492240
cn3	Gdf11^tm1.1Vlcg/Gdf11^tm1.1Vlcg Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546222
cn4	Dicer1^tm1.1Vlcg/Dicer1^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546213
cn5	Sost^{tm1(KOMP)Vlcg}/Sost^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546242
cn6	Drosha^tm2.1Vlcg/Drosha^tm3Vlcg Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546235
cn7	Dll4^tm2.1Vlcg/Dll4⁺ Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546216

Allelic Composition	Nipbl^{Gt(EUCE313f02)1.1Hmgu}/Nipbl⁺ Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)1.1Hmgu} mutation (0 available); any Nipbl mutation (125 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atrial septal defect ( J:236978 )

• large defects in 33% of hearts at E17.5

Allelic Composition	Nipbl^{Gt(EUCE313f02)Hmgu}/Nipbl⁺ Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nipbl^{Gt(EUCE313f02)Hmgu} mutation (0 available); any Nipbl mutation (125 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:236978 )

N	• hearts lack atrial septal defects and are indistinguishable from wild-type

Allelic Composition	Gdf11^tm1.1Vlcg/Gdf11^tm1.1Vlcg Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11^tm1.1Vlcg mutation (0 available); any Gdf11 mutation (18 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft palate ( J:200671 )

• authors state that mice phenocopy Gdf11^tm1Sjl homozygotes

limbs/digits/tail

short tail ( J:200671 )

• authors state that mice phenocopy Gdf11^tm1Sjl homozygotes

digestive/alimentary system

cleft palate ( J:200671 )

• authors state that mice phenocopy Gdf11^tm1Sjl homozygotes

growth/size/body

cleft palate ( J:200671 )

• authors state that mice phenocopy Gdf11^tm1Sjl homozygotes

Allelic Composition	Dicer1^tm1.1Vlcg/Dicer1^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1.1Vlcg mutation (0 available); any Dicer1 mutation (96 available)
Dicer1^tm2.1Vlcg mutation (0 available); any Dicer1 mutation (96 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:200671 )

• authors state that mice resemble Dicer1^tm1Ghan

embryo

abnormal embryo development ( J:200671 )

• authors state that mice resemble Dicer1^tm1Ghan

Allelic Composition	Sost^{tm1(KOMP)Vlcg}/Sost^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sost^{tm1(KOMP)Vlcg} mutation (1 available); any Sost mutation (29 available)
Sost^tm2.1Vlcg mutation (0 available); any Sost mutation (29 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mineral density ( J:200671 )

increased bone volume ( J:200671 )

increased compact bone thickness ( J:200671 )

Allelic Composition	Drosha^tm2.1Vlcg/Drosha^tm3Vlcg Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drosha^tm2.1Vlcg mutation (0 available); any Drosha mutation (98 available)
Drosha^tm3Vlcg mutation (0 available); any Drosha mutation (98 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:200671 )

Allelic Composition	Dll4^tm2.1Vlcg/Dll4⁺ Tg(Nanog-cre)#Vlcg/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (23 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal angiogenesis ( J:200671 )

• severe as in Dll4^tm1Nwg heterozygotes

embryo

abnormal embryo development ( J:200671 )

• authors state that mice phenocopy Dll4^tm1Nwg heterozygotes

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