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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wwtr1tm1.2Eno
targeted mutation 1.2, Eric N Olson
MGI:5544290
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wwtr1tm1.2Eno/Wwtr1tm1.2Eno involves: 129S/SvEv MGI:5544300
cn2
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas MGI:5660349


Genotype
MGI:5544300
hm1
Allelic
Composition		 Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wwtr1tm1.2Eno mutation (0 available); any Wwtr1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Polycystic kidney disease in Wwtr1tm1.2Eno/Wwtr1tm1.2Eno mice

renal/urinary system

growth/size/body
polycystic kidney ( J:200670 )




Genotype
MGI:5660349
cn2
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (48 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (42 available)
Wwtr1tm1.2Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj

growth/size/body
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory