All Phenotypes Cd44<tm2Stpa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd44^tm2Stpa
targeted mutation 2, Steven T Pals
MGI:5544104

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd44^tm2Stpa/Cd44^tm2Stpa	B6.Cg-Cd44^tm2Stpa	MGI:5544116
cx2	Apc^Min/Apc⁺ Cd44^tm2Stpa/Cd44^tm2Stpa	involves: C57BL/6J	MGI:5544112
cx3	Apc^Min/Apc⁺ Cd44^tm1Stpa/Cd44^tm2Stpa	involves: C57BL/6J	MGI:5544114

Allelic Composition	Cd44^tm2Stpa/Cd44^tm2Stpa
Genetic Background	B6.Cg-Cd44^tm2Stpa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm2Stpa mutation (0 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:204874 )

N	• mice exhibit normal intestinal crypts

Allelic Composition	Apc^Min/Apc⁺ Cd44^tm2Stpa/Cd44^tm2Stpa
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Cd44^tm2Stpa mutation (0 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

mortality/aging

increased tumor-free survival time ( J:204874 )

• mice survive longer than Apc^Min heterozygotes

neoplasm

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

Allelic Composition	Apc^Min/Apc⁺ Cd44^tm1Stpa/Cd44^tm2Stpa
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Cd44^tm1Stpa mutation (0 available); any Cd44 mutation (67 available)
Cd44^tm2Stpa mutation (0 available); any Cd44 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:204874 )

• mice develop the same number of intestinal adenoma and microadenoma as in Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:204874 )

• mice develop the same number of intestinal adenoma and microadenoma as in Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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