Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm targeted mutation 2, David H Gutmann MGI:5543802 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased neuronal stem cell proliferation following transfection with a cre-expressing adenovirus
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• following transfection with a cre-expressing adenovirus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are born in Mendelian ratios but do not survive beyond 8 to 10 weeks
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• abnormal alimentary canal, ranging from severely swollen stomachs to blackened hindguts
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• blackened hindguts in some mice
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• severely swollen in some mice
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• mice become malnourished
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| N |
• cell proliferation and survival are normal in the cerebellum
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• GFAP+ and S100B+ without a change in proliferation or apoptosis rates
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• GFAP+ and S100B+ without a change in proliferation or apoptosis rates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal GFAP+ and S100B+ astrocytes cell numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal GFAP+ and S100B+ astrocytes cell numbers
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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