All Phenotypes Coq7<tm2Hek> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Coq7^tm2Hek
targeted mutation 2, Siegfried Hekimi
MGI:5532527

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coq7^tm2Hek/Coq7^tm2Hek	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5532532
cn2	Coq7^tm2Hek/Coq7^tm2Hek	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5532533
cn3	Coq7^tm1Hek/Coq7^tm2Hek Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5532534

Allelic Composition	Coq7^tm2Hek/Coq7^tm2Hek
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7^tm2Hek mutation (0 available); any Coq7 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:202240 )

• mice develop normally and are indistinguishable form wild-type mice

Allelic Composition	Coq7^tm2Hek/Coq7^tm2Hek
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7^tm2Hek mutation (0 available); any Coq7 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:202240 )

N	• mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit normal viability, growth and morphology without the addition of exogenous ubiquinone

increased cell death ( J:202240 )

• after exposure to glycolytic inhibition by 2-deoxyl-D-glucose (2-DG) or culture in galactose medium with or without vitamin K2, mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit reduced viability compared with control cells

• however, exogenous ubiquinine rescues viability

abnormal respiratory electron transport chain ( J:202240 )

• mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit impaired respiratory chain function with reduced complex II and II+III activity compared with control cells

• however, cells exhibit normal complex I and III activity and ATP synthesis

Allelic Composition	Coq7^tm1Hek/Coq7^tm2Hek Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7^tm1Hek mutation (0 available); any Coq7 mutation (29 available)
Coq7^tm2Hek mutation (0 available); any Coq7 mutation (29 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:202240 )

N	• mice exhibit normal mortality

liver/biliary system

liver/biliary system phenotype ( J:202240 )

N	• mice exhibit normal liver morphology

abnormal liver physiology ( J:202240 )

• mild reduction in respiratory capacity in liver mitochondria

• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function

cellular

abnormal respiratory electron transport chain ( J:202240 )

• mild reduction in respiratory capacity in liver mitochondria

• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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