All Phenotypes Bmi1<tm1.1Lees> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmi1^tm1.1Lees
targeted mutation 1.1, Jacqueline A Lees
MGI:5532395

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmi1^tm1.1Lees/Bmi1^tm1.1Lees	involves: 129S4/SvJae * C57BL/6	MGI:5704436
cn2	Bmi1^tm1.1Lees/Bmi1^tm1.1Lees Apc^tm2Cip/Apc⁺ Tg(Vil1-cre)20Syr/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2	MGI:5532577

Allelic Composition	Bmi1^tm1.1Lees/Bmi1^tm1.1Lees
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^tm1.1Lees mutation (1 available); any Bmi1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:204354 )

• mice are viable and fertile

Allelic Composition	Bmi1^tm1.1Lees/Bmi1^tm1.1Lees Apc^tm2Cip/Apc⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Cip mutation (0 available); any Apc mutation (154 available)
Bmi1^tm1.1Lees mutation (1 available); any Bmi1 mutation (33 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased alimentary system tumor incidence ( J:204354 )

• reduced visible and total lesions in the small intestine

decreased colon tumor incidence ( J:204354 )

decreased intestinal adenoma incidence ( J:204354 )

digestive/alimentary system

decreased alimentary system tumor incidence ( J:204354 )

• reduced visible and total lesions in the small intestine

decreased colon tumor incidence ( J:204354 )

decreased intestinal adenoma incidence ( J:204354 )

cellular

cellular phenotype ( J:204354 )

N	• no increase in apoptosis is observed in non tumor tissue

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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