Bmi1^tm1.1Lees
Targeted Allele Detail

Summary

• Symbol: Bmi1^tm1.1Lees
• Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1.1, Jacqueline A Lees
• MGI ID: MGI:5532395
• Synonyms: Bmi1^fl, Pcgf4
• Gene: Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
• Alliance: Bmi1^tm1.1Lees page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204354
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette was inserted in intron 3 upstream of loxP sites inserted in intron 3 and in intron 8. The selection cassette was subsequently deleted by crossing to a b-actin FLP mouse strain. Exons 4 to 8 were thus flanked by loxP sites. (J:204354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmi1 Mutation: 33 strains or lines available

References

• Original: J:204354 Maynard MA, et al., Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. 2014 Jul 10;33(28):3742-7
• All: 5 reference(s)