Apc^tm2Cip
Targeted Allele Detail

Summary

• Symbol: Apc^tm2Cip
• Name: APC, WNT signaling pathway regulator; targeted mutation 2, Christine Perret
• MGI ID: MGI:3775293
• Synonyms: Apc^3lox14, APC-Flox14, Apc^tm1Cpe
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2Cip page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94108
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 2.9-kb BamHI fragment containing a floxed PGKHprt mini-gene was inserted into the BamHI site 0.4 kb downstream of exon 14. A third loxP site was introduced into the EcoRV site 0.5-kb upstream of exon 14. (J:94108)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 151 strains or lines available

References

• Original: J:94108 Colnot S, et al., Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest. 2004 Dec;84(12):1619-30
• All: 11 reference(s)