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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Braftm1.1Brd
targeted mutation 1.1, Allan Bradley
MGI:5527388
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Braftm1.1Brd/Braf+
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL MGI:5528298
cn2
 		Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0
Trp53tm2Tyj/Trp53tm2Tyj 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL MGI:5528297
cn3
 		Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0 		involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:5528296


Genotype
MGI:5528298
cn1
Allelic
Composition		 Braftm1.1Brd/Braf+
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Brd mutation (0 available); any Braf mutation (58 available)
Cdkn2atm1.1Brn mutation (1 available); any Cdkn2a mutation (62 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:199307 )
• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)
increased carcinoma incidence ( J:199307 )
• 6.4 fold increase in carcinomas relative to mice with unmutated Cdkn2a alleles

digestive/alimentary system
increased intestinal adenoma incidence ( J:199307 )
• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)




Genotype
MGI:5528297
cn2
Allelic
Composition		 Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0
Trp53tm2Tyj/Trp53tm2Tyj
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Brd mutation (0 available); any Braf mutation (58 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor pathology ( J:199307 )
• invasiveness of cancers considerably increased
• 56% of mice at 10-20 months
increased metastatic potential ( J:199307 )
• 25% of cancerous mice have metastases




Genotype
MGI:5528296
cn3
Allelic
Composition		 Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Brd mutation (0 available); any Braf mutation (58 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal mucosa morphology ( J:199307 )
• increased number of proliferating cells (hyperproliferation) in the mucosa
• levels of apoptosis are unchanged
abnormal crypts of Lieberkuhn morphology ( J:199307 )
• generalized crypt hyperplasia affecting almost all crypts
abnormal large intestine crypts of Lieberkuhn morphology ( J:199307 )
• crypt hyperplasia and mucosal protrusions
abnormal large intestine morphology ( J:199307 )
• significantly elongated and thickened
increased large intestine length ( J:199307 )
• significantly elongated
abnormal small intestine morphology ( J:199307 )
• significantly elongated and thickened
abnormal small intestinal villus morphology ( J:199307 )
• villi are thickened and deformed
branched small intestinal villi ( J:199307 )
• villi are often branched
increased small intestine length ( J:199307 )
• significantly elongated
intestine polyps ( J:199307 )
• focal serrated epithelial formations with cytomorphologic features of human microvesicular or goblet rich hyperplastic polyps
• predominantly in the small intestine
increased gastrointestinal tumor incidence ( J:199307 )
• macroscopic tumors and dysplasia in some mice at 2-3 months of age
• all mice with dysplastic lesions by 10 months
increased intestinal adenoma incidence ( J:199307 )
• dysplastic lesions in 10 month old mice with features of human serrated adenomas
• crypt elongation and serrated eosinophilic adenomatous epithelium
• only 5 of 95 tumors found were in the large intestine
• increased proliferation in murine adenoma with dysplasia

neoplasm
increased gastrointestinal tumor incidence ( J:199307 )
• macroscopic tumors and dysplasia in some mice at 2-3 months of age
• all mice with dysplastic lesions by 10 months
increased intestinal adenoma incidence ( J:199307 )
• dysplastic lesions in 10 month old mice with features of human serrated adenomas
• crypt elongation and serrated eosinophilic adenomatous epithelium
• only 5 of 95 tumors found were in the large intestine
• increased proliferation in murine adenoma with dysplasia
increased carcinoma incidence ( J:199307 )
• in 8.3% of mice under 10 months of age
• in 13.8% of mice older than 10 months

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:199307 )
• generalized crypt hyperplasia affecting almost all crypts
abnormal large intestine crypts of Lieberkuhn morphology ( J:199307 )
• crypt hyperplasia and mucosal protrusions




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory