Analysis Tools
behavior/neurological
| N |
• locomotor activity is similar to littermate controls at 30-45 days of age
|
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• normal weight gain and post-weaning food intake during early life (0 to 32 days and 23 to 32 days, respectively), increase food intake with advancing age, starting after 32 days of age
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• food intake almost doubles after 40 days of restricted feeding
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polyphagia
(
J:199365
)
|
• no difference when analyzed over a 4-day interval
• subtle increase in food intake is noticeable when monitored over 50 days (ages 34 to 84 days), with the onset of obesity preceding hyperphagia
• age-dependent in older mice and independent of body weight
|
growth/size/body
|
• as a percent of total body mass
|
|
• gradually become extremely obese starting after 32 days of age, with onset of obesity preceding hyperphagia
|
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• mice gain more weight even when food intake is restricted to match littermate controls
• increase weight gain in mutant mice unless food intake is restricted to 10% (females) and 13% (males) less than that of littermate controls
|
adipose tissue
|
• enlarged brown adipose tissue depots
|
|
• increase in visceral adiposity
|
|
• greater than twice the size of cells in controls
|
liver/biliary system
|
• normal while on a regular chow diet but much greater hepatic steatosis on a high-fat diet
|
homeostasis/metabolism
| N |
• fasting insulin, glucose tolerance, corticosterone levels, thyroid hormone levels, energy expenditure, respiratory quotient, and body temperature are similar to controls in adult obese mice
|
|
• in adult obese mice
|
 |
• significantly reduced
|
|
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• significantly reduced
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digestive/alimentary system
|
• no difference in calories absorption
|
