Analysis Tools
mortality/aging
|
• some mice die between P5 and P15
|
reproductive system
 N |
• female mice exhibit normal fertility and ovary morphology
|
 |
• increased in the seminiferous tubules
|
|
|
• in all mice
|
|
|
• heterogeneous testicular degeneration
|
|
|
• reduced thickness with diminished post-meiotic germ cells and scattered large vacuoles
|
small testis
(
J:198685
)
|
|
|
azoospermia
(
J:198685
)
|
|
• almost completely in some mice
• however, some mice are normospermia
|
|
|
• in some mice
• however, some mice are normospermia
|
|
|
• in pachytene stage in some mice
|
|
|
• 2 of 9 male mice produce litter sizes ranging from 2 and 9 pups
|
|
|
• in 7 of 9 mice
|
|
|
• 2 of 9 male mice produce litter sizes ranging from 2 and 9 pups
|
growth/size/body
| N |
• adult mice exhibit normal body weight and size
|
|
• at E19.5
|
|
• at E17.5 and E19.5
|
embryo
|
• necrosis in the placental junctional zone at E17.5 and to a lesser extent at E19.5
|
|
• in the placental junctional zone at E17.5 and to a lesser extent at E19.5
|
|
• thin starting affecting all layers from E17.5
|
cellular
azoospermia
(
J:198685
)
|
|
• almost completely in some mice
• however, some mice are normospermia
|
|
|
• in some mice
• however, some mice are normospermia
|
|
|
• in pachytene stage in some mice
|
|
|
• increased in the seminiferous tubules
|
|
• in the placental junctional zone at E17.5 and to a lesser extent at E19.5
|
|
|
• in all mice
|
endocrine/exocrine glands
|
|
• heterogeneous testicular degeneration
|
|
|
• reduced thickness with diminished post-meiotic germ cells and scattered large vacuoles
|
small testis
(
J:198685
)
|
|
|
