Tex19.1^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Tex19.1^tm1.2Ics
• Name: testis expressed gene 19.1; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5519134
• Gene: Tex19.1 Location: Chr11:121036969-121039140 bp, + strand Genetic Position: Chr11, 85.0 cM
• Alliance: Tex19.1^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 1-3 containing the coding sequence. Western blot analysis confirmed the absence of protein expression in ES cells and testis. (J:198685)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex19.1 Mutation: 10 strains or lines available

References

• Original: J:198685 Tarabay Y, et al., The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development. Hum Reprod. 2013 Aug;28(8):2201-14
• All: 1 reference(s)