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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kirrel3tm1.1Jfcl
targeted mutation 1.1, Jean-Francois Cloutier
MGI:5517690
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl Not Specified MGI:5517700
cx2
 		Kirrel2tm2b(KOMP)Wtsi/Kirrel2tm2b(KOMP)Wtsi
Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl 		involves: C57BL/6N MGI:6287117
cx3
 		Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl
Tg(Vmn2r43-lacZ*)#Ddg/0 		Not Specified MGI:5517701


Genotype
MGI:5517700
hm1
Allelic
Composition		 Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel3tm1.1Jfcl mutation (0 available); any Kirrel3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• reduced coalescence of Kirrel3 and Kirrel2-expressing vomeronasal sensory neuron axons in the posterior accessory olfactory bulb

nervous system
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• reduced coalescence of Kirrel3 and Kirrel2-expressing vomeronasal sensory neuron axons in the posterior accessory olfactory bulb
abnormal olfactory bulb glomerular layer morphology ( J:198564 )
• slightly larger glomeruli in some regions of the anterior accessory olfactory bulb
• malformed, larger and fewer glomeruli in the posterior accessory olfactory bulb
• however, the number of vomeronasal sensory neurons in the vomeronasal organ is normal

behavior/neurological
decreased aggression towards male mice ( J:198564 )
• loss of male-male aggression
abnormal sexual interaction ( J:198564 )
• male mice respond sexually towards a male intruder mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• reduced coalescence of Kirrel3 and Kirrel2-expressing vomeronasal sensory neuron axons in the posterior accessory olfactory bulb

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• reduced coalescence of Kirrel3 and Kirrel2-expressing vomeronasal sensory neuron axons in the posterior accessory olfactory bulb

taste/olfaction
taste/olfaction phenotype ( J:198564 )
N
• vomeronasal sensory neurons axons reach the accessory olfactory bulb and segregate accurately
• the function of the main olfactory system is normal with normal latency to find hidden food




Genotype
MGI:6287117
cx2
Allelic
Composition		 Kirrel2tm2b(KOMP)Wtsi/Kirrel2tm2b(KOMP)Wtsi
Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel2tm2b(KOMP)Wtsi mutation (0 available); any Kirrel2 mutation (24 available)
Kirrel3tm1.1Jfcl mutation (0 available); any Kirrel3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:272414 )
N
• adult mice exhibit normal vomeronasal tract fasciculation with no differences in the segregation of apical and basal vomeronasal sensory neuron (VSN) axons in the anterior and posterior regions of the accessory olfactory bulb (AOB)
abnormal olfactory bulb glomerular layer morphology ( J:272414 )
• adult mice show severe disruption of the glomerular layer of AOB with loss of morphologically distinct glomeruli
• glomeruli in both the anterior and posterior regions of the AOB are severely disrupted and the boundaries between glomeruli are largely indistinguishable
abnormal synaptic bouton morphology ( J:272414 )
• the average size of presynaptic terminals in the glomerular layer of AOB is significantly larger than that in controls
• however, no change is observed in the average length of asymmetric or symmetric synapses
abnormal asymmetric synapse morphology ( J:272414 )
• mice show a significantly decreased number of asymmetric synapses in the glomerular layer of AOB relative to controls
• in contrast, the number of symmetric synapses (i.e. inhibitory inputs from periglomerular cells) in the AOB glomerular layer is similar to that in controls
abnormal excitatory synapse morphology ( J:272414 )
• mice show a significantly decreased number of asymmetric synapses (i.e. excitatory glutamatergic synapses of VSN axons onto mitral cell dendrites) in the glomerular layer of AOB relative to controls




Genotype
MGI:5517701
cx3
Allelic
Composition		 Kirrel3tm1.1Jfcl/Kirrel3tm1.1Jfcl
Tg(Vmn2r43-lacZ*)#Ddg/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel3tm1.1Jfcl mutation (0 available); any Kirrel3 mutation (36 available)
Tg(Vmn2r43-lacZ*)#Ddg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• early in postnatal development, Vmn2r43-expressing axons for more diffuse glomeruli than in wild-type mice

craniofacial
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• early in postnatal development, Vmn2r43-expressing axons for more diffuse glomeruli than in wild-type mice

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• early in postnatal development, Vmn2r43-expressing axons for more diffuse glomeruli than in wild-type mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:198564 )
• early in postnatal development, Vmn2r43-expressing axons for more diffuse glomeruli than in wild-type mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory