Kirrel3^tm1.1Jfcl
Targeted Allele Detail

Summary

• Symbol: Kirrel3^tm1.1Jfcl
• Name: kirre like nephrin family adhesion molecule 3; targeted mutation 1.1, Jean-Francois Cloutier
• MGI ID: MGI:5517690
• Synonyms: Kirrel3^-
• Gene: Kirrel3 Location: Chr9:34397190-34948012 bp, + strand Genetic Position: Chr9, 18.97 cM
• Alliance: Kirrel3^tm1.1Jfcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198564
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A membrane associated EGFP (GFP-F) and self-excising neomycin resistance cassette replaced the endogenous 18 amino acid signal sequence in exon 1. The final allele lacks the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in the brain, olfactory bulb and vomeronasal organ. (J:198564)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kirrel3 Mutation: 37 strains or lines available

References

• Original: J:198564 Prince JE, et al., Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development. 2013 Jun;140(11):2398-408
• All: 11 reference(s)