Phenotypes associated with this allele

• Allele Symbol: Tg(CSTG-NPM1/RARA)#Sjch
• Allele Name: transgene insertion, Sai-Juan Chen
• Allele ID: MGI:5517400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CSTG-NPM1/RARA)#Sjch/0	involves: C57BL/6	MGI:5517416

Genotype
MGI:5517416

tg1

• Allelic Composition: Tg(CSTG-NPM1/RARA)#Sjch/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:55196 )

• develop a spectrum of leukemias ranging from typical acute promyelocytic leukemia to chronic myeloid leukemia later in life, from 12-15 months of age

increased acute promyelocytic leukemia incidence ( J:55196 )

increased chronic myelocytic leukemia incidence ( J:55196 )

hematopoietic system

enlarged spleen ( J:55196 )

• mice that develop leukemia exhibit splenomegaly

increased spleen red pulp amount ( J:55196 )

• red pulp is expanded and filled with large amount of myeloid cells, including myeloblasts, promyelocytes, and mature forms

immune system

enlarged spleen ( J:55196 )

• mice that develop leukemia exhibit splenomegaly

increased spleen red pulp amount ( J:55196 )

• red pulp is expanded and filled with large amount of myeloid cells, including myeloblasts, promyelocytes, and mature forms

growth/size/body

enlarged spleen ( J:55196 )

• mice that develop leukemia exhibit splenomegaly