Tg(CSTG-NPM1/RARA)#Sjch
Transgene Detail

Summary

• Symbol: Tg(CSTG-NPM1/RARA)#Sjch
• Name: transgene insertion, Sai-Juan Chen
• MGI ID: MGI:5517400
• Synonyms: hCG-NPM-RARalpha
• Transgene: Tg(CSTG-NPM1/RARA)#Sjch Location: unknown
• Alliance: Tg(CSTG-NPM1/RARA)#Sjch page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CSTG-NPM1/RARA)#Sjch expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NPM1 (4869)

  Npm1	(MGI:106184)

  Transgene codes for a fusion protein of NPM1 and RARA.

  human

  RARA (5914)

  Rara	(MGI:97856)

  Transgene codes for a fusion protein of NPM1 and RARA.

• Mutation details: The human NPM1/RARA fusion gene is under the control of the human cathepsin-G promoter. The pound symbol (#) is used because lines are pooled. Lines 6, 16, 20, and 7 were pooled and analyzed in J:55196. (J:55196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55196 Cheng GX, et al., Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6318-23
• All: 1 reference(s)