All Phenotypes Prkar2b<tm3Gsm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkar2b^tm3Gsm
targeted mutation 3, G Stanley McKnight
MGI:5515221

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkar2b^tm3Gsm/Prkar2b^tm3Gsm	B6.Cg-Prkar2b^tm3Gsm	MGI:5515330
cn2	Prkar2b^tm3Gsm/Prkar2b^tm3Gsm	B6.Cg-Prkar2b^tm3Gsm	MGI:5515331
cn3	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Slc32a1^tm2(cre)Lowl/Slc32a1⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5515339
cn4	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5515332
cn5	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ppp1r1b-cre)1Meeh/0	involves: C57BL/6	MGI:5515335
cn6	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺	involves: C57BL/6	MGI:5515336
cn7	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Syn1-cre)671Jxm/0	involves: C57BL/6 * CBA	MGI:5515333
cn8	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ins2-cre)25Mgn/0	involves: C57BL/6 * DBA	MGI:5515338
cn9	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0	involves: C57BL/6 * FVB/N	MGI:5515337
cn10	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:5515334

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm3Gsm
Genetic Background	B6.Cg-Prkar2b^tm3Gsm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal food intake ( J:196157 )

hyperactivity ( J:196157 )

growth/size/body

decreased body weight ( J:196157 )

decreased susceptibility to diet-induced obesity ( J:196157 )

homeostasis/metabolism

decreased circulating insulin level ( J:196157 )

decreased circulating leptin level ( J:196157 )

decreased circulating cholesterol level ( J:196157 )

decreased circulating LDL cholesterol level ( J:196157 )

decreased circulating VLDL cholesterol level ( J:196157 )

abnormal energy expenditure ( J:196157 )

increased energy expenditure ( J:196157 )

• increased energy expenditure based on total body mass when active but not based on lean body mass at rest

• energy expenditure significantly elevated during dark phase when active

decreased susceptibility to diet-induced obesity ( J:196157 )

increased respiratory quotient ( J:196157 )

• increased respiratory exchange rate in males in both light and dark phase

• respiratory exchange rate of females is normal

improved glucose tolerance ( J:196157 )

decreased triglyceride level ( J:196157 )

decreased liver triglyceride level ( J:196157 )

liver/biliary system

decreased liver triglyceride level ( J:196157 )

decreased susceptibility to hepatic steatosis ( J:196157 )

adipose tissue

decreased white adipose tissue amount ( J:196157 )

decreased percent body fat/body weight ( J:196157 )

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm3Gsm
Genetic Background	B6.Cg-Prkar2b^tm3Gsm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:196157 )

• significant weight gain occurs after viral AAV1-cre-GFP is injected into the hypothalamus

adipose tissue

increased total body fat amount ( J:196157 )

• increased fat mass after viral AAV1-cre-GFP is injected into the hypothalamus

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Slc32a1^tm2(cre)Lowl/Slc32a1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Slc32a1^tm2(cre)Lowl mutation (2 available); any Slc32a1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is reversed

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• lean body mass is similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• fat pad weights are similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Fabp4-cre)1Rev/0
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:196157 )

• hyper-locomotor activity is retained

adipose tissue

decreased total body fat amount ( J:196157 )

decreased gonadal fat pad weight ( J:196157 )

• reproductive fat pads weigh significantly less in both males and females

growth/size/body

decreased body weight ( J:196157 )

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ppp1r1b-cre)1Meeh/0
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior comparable to controls

growth/size/body

decreased lean body mass ( J:196157 )

• lean body weight remains low

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• serum leptin levels remain low

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (68 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:196157 )

• remain hyperactive

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• adiposity similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior restored to normal

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight restored to normal

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• major fat pads are comparable to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: C57BL/6 * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is reduced

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight similar to controls • lean body mass is similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• adiposity similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is lost

adipose tissue

decreased total body fat amount ( J:196157 )

• low adiposity

growth/size/body

decreased body weight ( J:196157 )

• low body weight

• lean body

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior restored to normal

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight restored to normal

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• major fat pads are comparable to controls

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