Phenotypes associated with this allele

• Allele Symbol: Sox11^tm1.2Llei
• Allele Name: targeted mutation 1.2, Lei Lei
• Allele ID: MGI:5510958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox11^tm1.2Llei/Sox11^tm1.2Llei	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5510984

Genotype
MGI:5510984

hm1

• Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:198233 )

• mice die shortly after birth

nervous system

increased neuron apoptosis ( J:198233 )

• at E11.5 in the trigeminal ganglion

abnormal neuron differentiation ( J:198233 )

• fewer neurons are generated in the cortex

• marker expression indicates reduction of hippocampal progenitors and immature neurons during embryogenesis abnormal neuronal differentiation of embryonic neural progenitor cells in vitro and in vivo

abnormal neuronal precursor proliferation ( J:198233 )

• decreased proliferation in the neuroepithelium from E11.5 to P0

abnormal cortical ventricular zone morphology ( J:198233 )

• thin at E12.5 and E17.5

decreased brain size ( J:198233 )

• as early as E11.5

abnormal hippocampus morphology ( J:198233 )

• disorganized

abnormal hippocampus CA2 region morphology ( J:198233 )

• CA2/3 region split into two bundles

abnormal hippocampus CA3 region morphology ( J:198233 )

• CA2/3 region split into two bundles

abnormal dentate gyrus morphology ( J:198233 )

• scattered cells

small hippocampus ( J:198233 )

abnormal cerebral cortex morphology ( J:198233 )

• reduced neuronal layer due to fewer neurons generated

thin cerebral cortex ( J:198233 )

• at P0

abnormal olfactory bulb morphology ( J:198233 )

• disorganized without a visible mitral cell layer

small olfactory bulb ( J:198233 )

abnormal cerebellum morphology ( J:198233 )

• underdeveloped

small cerebellum ( J:198233 )

abnormal embryonic/fetal subventricular zone morphology ( J:198233 )

• thin at E12.5 and E17.5

cellular

increased neuron apoptosis ( J:198233 )

• at E11.5 in the trigeminal ganglion

abnormal neuron differentiation ( J:198233 )

• fewer neurons are generated in the cortex

• marker expression indicates reduction of hippocampal progenitors and immature neurons during embryogenesis abnormal neuronal differentiation of embryonic neural progenitor cells in vitro and in vivo

abnormal neuronal precursor proliferation ( J:198233 )

• decreased proliferation in the neuroepithelium from E11.5 to P0