Sox11^tm1.2Llei
Targeted Allele Detail

Summary

• Symbol: Sox11^tm1.2Llei
• Name: SRY (sex determining region Y)-box 11; targeted mutation 1.2, Lei Lei
• MGI ID: MGI:5510958
• Gene: Sox11 Location: Chr12:27384263-27392573 bp, - strand Genetic Position: Chr12, 9.95 cM, cytoband A3
• Alliance: Sox11^tm1.2Llei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198233
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of the coding exon. An additional loxP site was inserted downstream of the coding exon. Flp-mediated recombination removed the neomycin resistance cassette and left the coding exon floxed. Cre-mediated recombination removed the coding exon. (J:198233)

Expression

In Mice Carrying this Mutation:	45 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox11 Mutation: 14 strains or lines available

References

• Original: J:198233 Wang Y, et al., Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn. 2013 Jun;242(6):638-53
• All: 2 reference(s)