Phenotypes associated with this allele

• Allele Symbol: Rorb^{tm1.1(cre)Hze}
• Allele Name: targeted mutation 1.1, Hongkui Zeng
• Allele ID: MGI:5507855
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rorb^tm1.1(cre)Hze/Rorb^+	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5508524
ht2	Rorb^tm1.1(cre)Hze/Rorb^hstp	involves: 129S6/SvEvTac * C57BL/6J	MGI:7505589
cn3	Gpr158^tm1.1Jdw/Gpr158^tm1.1Jdw Rorb^tm1.1(cre)Hze/Rorb^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl	MGI:8324945
cn4	Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw Rorb^tm1.1(cre)Hze/Rorb^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl	MGI:8324948

Genotype
MGI:5508524

ht1

• Allelic Composition: Rorb^{tm1.1(cre)Hze}/Rorb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:146821 )

• mice are viable and fertile with no gross physical or behavioral abnormalities

Genotype
MGI:7505589

ht2

• Allelic Composition: Rorb^{tm1.1(cre)Hze}/Rorb^hstp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

behavior/neurological

abnormal gait ( J:337403 )

• compound heterozygotes pull each rear leg up to the body as they step

Genotype
MGI:8324945

cn3

• Allelic Composition: Gpr158^tm1.1Jdw/Gpr158^tm1.1Jdw; Rorb^{tm1.1(cre)Hze}/Rorb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl

nervous system

abnormal dendritic spine morphology ( J:372545 )

• dendritic spines of neurons are shifted toward a less mature phenotype, with a decrease in the fraction of mature mushroom-type spines and a concomitant increase in immature filopodia-type protrusions indicating attenuation of dendritic spin maturation

• however, dendritic spine density is unaffected

decreased miniature excitatory postsynaptic current frequency ( J:372545 )

• acute cortical sections from P15-21 mice show a strong reduction in the frequency of miniature excitatory post-synaptic currents (mEPSCs)

• however, amplitude and decay time of mEPSCs are not affected

Genotype
MGI:8324948

cn4

• Allelic Composition: Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw; Rorb^{tm1.1(cre)Hze}/Rorb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl

nervous system

abnormal dendritic spine morphology ( J:372545 )

• dendritic spines of neurons shift toward a more mature phenotype, with a decrease in immature filopodia-type protrusions and a concomitant increase in mature mushroom-type spines indicating promotion of dendritic spine maturation

• neurons from mice injected with adenoviruses expressing TRE-DIO-FLPo and TRE-fDIO-tdTomato-IRES-tTA into the barrel cortex at P0 exhibit more spine apparatus-containing dendritic spines

• however, dendritic spine density is unaffected