All Phenotypes Tg(Rax-cre)1Zkoz MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax6^tm1.1Zkoz/Pax6^Sey-Neu Tg(Rax-cre)1Zkoz/0	involves: 102/El * C3H/Rl	MGI:5567090
cn2	Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi} Tg(Rax-cre)1Zkoz/0	involves: C57BL/6N	MGI:6457284
cn3	Pax6^tm1.1Zkoz/Pax6^tm1.1Zkoz Tg(Rax-cre)1Zkoz/0	Not Specified	MGI:5567085

Allelic Composition	Pax6^tm1.1Zkoz/Pax6^Sey-Neu Tg(Rax-cre)1Zkoz/0
Genetic Background	involves: 102/El * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
Pax6^tm1.1Zkoz mutation (0 available); any Pax6 mutation (90 available)
Tg(Rax-cre)1Zkoz mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

absent lens vesicle ( J:208421 )

• at E11

abnormal optic placode morphology ( J:208421 )

• does not form lens vesicle at E11

• optic vesicle arrests at E11 or shows only a small invagination into an optic cup like structure

aphakia ( J:208421 )

• at E11

abnormal optic cup morphology ( J:208421 )

• defective lens/optic cup formation at E11

Allelic Composition	Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi} Tg(Rax-cre)1Zkoz/0
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2c(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (23 available)
Tg(Rax-cre)1Zkoz mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

adipose tissue phenotype ( J:287419 )

N	• mice exhibit normal adaptive thermogenesis under any lighting condition

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:208421 )

N	• retinal progenitor cell characteristics are maintained at E10.5

absent amacrine cells ( J:208421 )

• at E15.5

abnormal lens morphology ( J:208421 )

• occasionally observe morphological abnormalities that interfere with lens pit/optic cup formation

abnormal optic cup morphology ( J:208421 )

• at E10.5

abnormal retina development ( J:208421 )

• expression analysis indicates a defect in the retina-specific differentiation program

abnormal retina progenitor cell morphology ( J:208421 )

• significant reduction of retinal progenitor cell from E10.5 to E14.5

microphthalmia ( J:208421 )

• at postnatal stages

abnormal retina layer morphology ( J:208421 )

• absent of lamination at P0 and hardly distinguishable retinal cells at postnatal stages

• the differentiated cell layer is not established at E14.5-E16.5

decreased total retina thickness ( J:208421 )

• from E10.5 to P0

retina hypoplasia ( J:208421 )

• at E14.5 and E16.5

abnormal eye physiology ( J:208421 )

• rapid decrease of proliferating BrdU+ retinal progenitor cells at E14.5 to E16.5 onwards, where almost no BrdU+ cells are present in the retina

• lower overall progenitor proliferation at E11.5 and E13

increased retina apoptosis ( J:208421 )

• increase in apoptosis at E13.5 and E14.5, although no significant difference at younger ages (E10.5-E15.5)

cellular

abnormal cell cycle ( J:208421 )

• premature cell cycle exit in retinal progenitor cells

abnormal cell cycle checkpoint function ( J:208421 )

• G1+G2+M phase is increased in retinal progenitor cells at E11.5 and E13

abnormal mitosis ( J:208421 )

• decreased proportion of retinal progenitor cells stained for M-phase marker at E14.5, while no difference is detected in E10.5, E11.5, and E14.5 embryos.