All Phenotypes Sec24c<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sec24c^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5501469

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5896386
cn2	Meox2^tm1(cre)Sor/Meox2⁺ Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5896387
cn3	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA * SJL	MGI:5896384
cn4	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * SJL	MGI:5896385
cn5	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0	involves: C57BL/6 * SJL	MGI:5896388

Allelic Composition	Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (30 available)
Sec24c^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Sec24c mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:232065 )

N	• no defects in pancreas morphology are detected

growth/size/body

growth/size/body region phenotype ( J:232065 )

N	• no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N	• no differences in plasma cholesterol, triglyceride or insulin levels

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Sec24c^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Sec24c mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:232065 )

• all die before 2 weeks of age

Allelic Composition	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24c^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Sec24c mutation (39 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:232065 )

N	• no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N	• no differences in plasma cholesterol or triglyceride levels

Allelic Composition	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24c^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Sec24c mutation (39 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:232065 )

N	• no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N	• no differences in plasma cholesterol or triglyceride levels

Allelic Composition	Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24c^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Sec24c mutation (39 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:232065 )

• viable and fertile

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