All Phenotypes Nfkbiz<tm1.1Muta> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nfkbiz^tm1.1Muta
targeted mutation 1.1, Tatsushi Muta
MGI:5501251

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lyz2^tm1(cre)Ifo/Lyz2⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta	involves: 129P2/OlaHsd * C57BL/6	MGI:5501492
cn2	Cd79a^tm1(cre)Reth/Cd79a⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta	involves: BALB/c * C57BL/6	MGI:5501491
cn3	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(KRT5-cre)1Tak/?	involves: C3H * C57BL/6	MGI:5501493
cn4	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(CAG-cre)13Miya/?	involves: C57BL/6	MGI:5501489
cn5	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(Lck-cre)1Jtak/?	involves: C57BL/6	MGI:5501490

Allelic Composition	Lyz2^tm1(cre)Ifo/Lyz2⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nfkbiz^tm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:194832 )

N	• lack inflammation up to 30 weeks of age

Allelic Composition	Cd79a^tm1(cre)Reth/Cd79a⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Nfkbiz^tm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:194832 )

N	• lack inflammation up to 30 weeks of age

Allelic Composition	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(KRT5-cre)1Tak/?
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiz^tm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(KRT5-cre)1Tak mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

dermatitis ( J:194832 )

• inflammation present

vision/eye

increased lacrimal gland apoptosis ( J:194832 )

• increased apoptosis

integument

dermatitis ( J:194832 )

• inflammation present

endocrine/exocrine glands

increased lacrimal gland apoptosis ( J:194832 )

• increased apoptosis

cellular

increased lacrimal gland apoptosis ( J:194832 )

• increased apoptosis

Allelic Composition	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(CAG-cre)13Miya/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiz^tm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(CAG-cre)13Miya mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

eyelid edema ( J:194832 )

• swelling as early as 2 weeks of age

• inflammatory effects in all mice by 8 weeks

immune system

dermatitis ( J:194832 )

• mostly in the periocular region initially

• eventually spreads over the whole face, skin erosion and hair loss

integument

dermatitis ( J:194832 )

• mostly in the periocular region initially

• eventually spreads over the whole face, skin erosion and hair loss

homeostasis/metabolism

eyelid edema ( J:194832 )

• swelling as early as 2 weeks of age

• inflammatory effects in all mice by 8 weeks

growth/size/body

eyelid edema ( J:194832 )

• swelling as early as 2 weeks of age

• inflammatory effects in all mice by 8 weeks

craniofacial

eyelid edema ( J:194832 )

• swelling as early as 2 weeks of age

• inflammatory effects in all mice by 8 weeks

Allelic Composition	Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(Lck-cre)1Jtak/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiz^tm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(Lck-cre)1Jtak mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:194832 )

N	• lack inflammation up to 30 weeks of age

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