Analysis Tools
growth/size/body
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• at 5 weeks, males and females have lower body weights than control littermates; female weight differences are greatest at 5 weeks, but are also lower at other post-weaning ages (weeks 4 through 8) while difference is smaller but still significant in males at 5 weeks
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homeostasis/metabolism
| N |
• at 8 weeks, circulating thyroid-stimulating hormone (TSH) levels are not different in mutants and controls
• serum levels of total thyroxine (T4) are within normal ranges for male and female mutants
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• following dietary-induced hypothyroidism for 4 weeks, mutants have a 48-fold increase in serum TSH levels, but this increase is inferior to the 80-fold increased serum TSH seen in controls fed the same low iodine diet for 4 weeks
• mutant thus show a blunted TSH response to hypothyroidism relative to controls
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endocrine/exocrine glands
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• thyroid gland volume is smaller in mutants than in controls; however, follicular size and height of follicular epithelia are indistinguishable from controls
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