Phenotypes associated with this allele

• Allele Symbol: Slc5a6^tm1.1Said
• Allele Name: targeted mutation 1.1, Hamid M Said
• Allele ID: MGI:5493496
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc5a6^tm1.1Said/Slc5a6^tm1.1Said Tg(Vil1-cre)997Gum/?	involves: C57BL/6	MGI:5493511
cn2	Slc5a6^tm1.1Said/Slc5a6^tm1.1Said Tg(Vil1-cre/ERT2)23Syr/0	involves: C57BL/6 * DBA/2	MGI:6721401

Genotype
MGI:5493511

cn1

• Allelic Composition: Slc5a6^tm1.1Said/Slc5a6^tm1.1Said; Tg(Vil1-cre)997Gum/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194700 )

• about 2/3 of mice die prematurely between 6 and 10 weeks of age

growth/size/body

postnatal growth retardation ( J:194700 )

• significant postnatal growth retardation

slow postnatal weight gain ( J:194700 )

• mean body weight at 6-10 weeks of age is significantly lower than sex matched control litter mates

skeleton

abnormal appendicular skeleton morphology ( J:194700 )

decreased bone mineral density of humerus ( J:194700 )

• decreased bone density of the humoral heads

short femur ( J:194700 )

short tibia ( J:194700 )

abnormal pelvic girdle bone morphology ( J:194700 )

• shorter pelvic bones

decreased bone mineral density of femur ( J:194700 )

• decreased bone density of the femoral heads

behavior/neurological

lethargy ( J:194700 )

hunched posture ( J:194700 )

• hunched back posture

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:194700 )

• increased neutrophiles in mucosa

• mucosal edema

abnormal large intestine morphology ( J:194700 )

abnormal large intestine crypts of Lieberkuhn morphology ( J:194700 )

• chronic focal cryptitis/crypt abscesses

distended cecum ( J:194700 )

• distended and thinned walls

abnormal small intestine morphology ( J:194700 )

• focal areas of low grade dysplasia

distended ileum ( J:194700 )

• distended and thinned walls

decreased small intestinal villus size ( J:194700 )

• shorter small intestine villi

abnormal vitamin absorption ( J:194700 )

• no biotin or pantothenic acid uptake in the jejunum

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:194700 )

N • pancreas normal

abnormal large intestine crypts of Lieberkuhn morphology ( J:194700 )

• chronic focal cryptitis/crypt abscesses

homeostasis/metabolism

abnormal vitamin absorption ( J:194700 )

• no biotin or pantothenic acid uptake in the jejunum

abnormal vitamin level ( J:194700 )

• lower biotin levels in the liver

nervous system

nervous system phenotype ( J:194700 )

N • brain normal

cardiovascular system

cardiovascular system phenotype ( J:194700 )

N • heart normal

respiratory system

respiratory system phenotype ( J:194700 )

N • lungs normal

liver/biliary system

liver/biliary system phenotype ( J:194700 )

N • liver normal

immune system

immune system phenotype ( J:194700 )

N • spleen normal

renal/urinary system

renal/urinary system phenotype ( J:194700 )

N • kidneys normal

limbs/digits/tail

decreased bone mineral density of humerus ( J:194700 )

• decreased bone density of the humoral heads

short femur ( J:194700 )

short tibia ( J:194700 )

Genotype
MGI:6721401

cn2

• Allelic Composition: Slc5a6^tm1.1Said/Slc5a6^tm1.1Said; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

digestive/alimentary system

intestinal hemorrhage ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

abnormal intestinal epithelium morphology ( J:307482 )

• significantly increased intestinal permeability after tamoxifen-induction of intestinal epithelium-specific knockout

abnormal large intestine crypts of Lieberkuhn morphology ( J:307482 )

• cryptitis and absence of crypts in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

crypts of Lieberkuhn abscesses ( J:307482 )

• in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

intestinal ulcer ( J:307482 )

• mucosal erosion in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

decreased colon length ( J:307482 )

• after tamoxifen-induction of intestinal epithelium-specific knockout

• virtually normal colon length after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

diarrhea ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

abnormal intestinal epithelium physiology ( J:307482 )

• significantly increased intestinal permeability after tamoxifen-induction of intestinal epithelium-specific knockout

cecum inflammation ( J:307482 )

• severe chronic inflammation with cryptitis, crypt abscesses, and absence of crypts after tamoxifen-induction of intestinal epithelium-specific knockout

small intestinal inflammation ( J:307482 )

• acute inflammation with significant increase in neutrophil infiltration after tamoxifen-induction of intestinal epithelium-specific knockout

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:307482 )

• cryptitis and absence of crypts in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

crypts of Lieberkuhn abscesses ( J:307482 )

• in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

cardiovascular system

intestinal hemorrhage ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

growth/size/body

weight loss ( J:307482 )

• progressive decline in body weight after tamoxifen-induction of intestinal epithelium-specific knockout

• virtually normal weight after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

immune system

cecum inflammation ( J:307482 )

• severe chronic inflammation with cryptitis, crypt abscesses, and absence of crypts after tamoxifen-induction of intestinal epithelium-specific knockout

small intestinal inflammation ( J:307482 )

• acute inflammation with significant increase in neutrophil infiltration after tamoxifen-induction of intestinal epithelium-specific knockout

mortality/aging

premature death ( J:307482 )

• 50% of mice die within 8-10 days after tamoxifen-induction of intestinal epithelium-specific knockout

• normal 10-day survival after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics