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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrltm1.1Jcco
targeted mutation 1.1, Joseph C Corbo
MGI:5490568
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrltm1.1Jcco/Nrltm1.1Jcco involves: C57BL/6 * CBA MGI:5490592


Genotype
MGI:5490592
hm1
Allelic
Composition		 Nrltm1.1Jcco/Nrltm1.1Jcco
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1.1Jcco mutation (0 available); any Nrl mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Adult rods are reprogrammed into cone-like cells in Nrltm1.1Jcco/Nrltm1.1Jcco and Nrltm1Asw/Nrltm1Asw retinas

vision/eye
abnormal retina photoreceptor morphology ( J:193697 )
• rods are reprogrammed into cones as in Nrltm1Asw homozygotes
abnormal cone electrophysiology ( J:193697 )
• increased photopic a and b wave amplitudes
abnormal rod electrophysiology ( J:193697 )
• decreased scotopic a and b wave amplitudes

nervous system
abnormal retina photoreceptor morphology ( J:193697 )
• rods are reprogrammed into cones as in Nrltm1Asw homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory