Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Nrltm1Asw Name: neural retina leucine zipper gene; targeted mutation 1, Anand Swaroop MGI ID: MGI:2152376 Synonyms: cone-full, Nrl- Gene: Nrl  Location: Chr14:55756972-55762438 bp, - strand  Genetic Position: Chr14, 28.19 cM Alliance: Nrltm1Asw page

Adult rods are reprogrammed into cone-like cells in Nrltm1.1Jcco/Nrltm1.1Jcco and Nrltm1Asw/Nrltm1Asw retinas Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:71808
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced the entire coding region (exons 2 and 3). Immunoblot analysis did not detect protein in retina from 10 day old homozygous mutant mice. RT-PCR studies of retina from 10 day old homozygous mutant mice did not detect mRNA. (J:78692)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	52119 assay results 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrl Mutation:	17 strains or lines available

Original:	J:71808 Swain PK, et al., Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. J Biol Chem. 2001 Sep 28;276(39):36824-30
All:	122 reference(s)