Phenotypes associated with this allele

• Allele Symbol: Kif14^lag
• Allele Name: laggard
• Allele ID: MGI:5488954
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif14^lag/Kif14^lag	B6.D2(129X1)-Kif14^lag	MGI:5910739
cx2	Kif14^lag/Kif14^lag Tg(CAG-Kif14)28LTskk/0	involves: 129X1/SvJ * C57BL/6JJmsSlc * C57BL/6NJcl * DBA/2NJcl	MGI:5488961

Genotype
MGI:5910739

hm1

• Allelic Composition: Kif14^lag/Kif14^lag
• Genetic Background: B6.D2(129X1)-Kif14^lag

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:195809 )

• all mice die by P21

nervous system

abnormal cerebellar granule cell migration ( J:195809 )

• arrested in the outer granule layer with few granule cells in the inner granule layer

decreased brain weight ( J:195809 )

• at P1 and worsening with time

abnormal cerebral cortex morphology ( J:195809 )

• disrupted laminar structures, especially the supra-granular layers

• reduced size

ectopic cerebral cortex pyramidal cells ( J:195809 )

• in layer 1

thin cerebral cortex ( J:195809 )

abnormal olfactory bulb morphology ( J:195809 )

• transparent parenchyma

small olfactory bulb ( J:195809 )

abnormal cerebellar cortex morphology ( J:195809 )

• reduced size

abnormal Purkinje cell dendrite morphology ( J:195809 )

• absence of dendritic arborization on Purkinje cells

ectopic Purkinje cell ( J:195809 )

• scattered cell bodies

cerebellum hypoplasia ( J:195809 )

abnormal spinal cord morphology ( J:195809 )

• transparent parenchyma

abnormal oligodendrocyte physiology ( J:195809 )

• despite normal numbers, oligodendrocytes fail to form myelin sheaths indicating a failure of maturation

demyelination ( J:195809 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:195809 )

• uncontrolled movement at P14

tremors ( J:195809 )

• during the early postnatal week

impaired balance ( J:195809 )

• at P10 mice cannot balance on a beam

weakness ( J:195809 )

• progressive

abnormal locomotor coordination ( J:195809 )

• uncoordinated locomotion during the early postnatal week

ataxia ( J:195809 )

• during the early postnatal week

• by P10, worsening with time

abnormal gait ( J:195809 )

• wide and uncoordinate with frequent falls

cellular

increased apoptosis ( J:195809 )

• in the outer granule cell layer at P14

• at E15.5 in the cortex

abnormal cerebellar granule cell migration ( J:195809 )

• arrested in the outer granule layer with few granule cells in the inner granule layer

decreased cell proliferation ( J:195809 )

• at E12.5 and E15.5 in the cortex

growth/size/body

microcephaly ( J:195809 )

• during the early postnatal week

decreased body size ( J:195809 )

• at P14

decreased body weight ( J:195809 )

• after the first week of life

slow postnatal weight gain ( J:195809 )

• failure to gain weight

Genotype
MGI:5488961

cx2

• Allelic Composition: Kif14^lag/Kif14^lag; Tg(CAG-Kif14)28LTskk/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6JJmsSlc * C57BL/6NJcl * DBA/2NJcl

behavior/neurological

behavior/neurological phenotype ( J:195809 )

N • ataxia and balance defects observed in Kif14^lag homozygotes are rescued

nervous system

nervous system phenotype ( J:195809 )

N • the size of the cerebral and cerebellar cortices are normal

N • the parenchyma of the olfactory bulb and spine cord are normal