Kif14^lag
Spontaneous Allele Detail

Summary

• Symbol: Kif14^lag
• Name: kinesin family member 14; laggard
• MGI ID: MGI:5488954
• Gene: Kif14 Location: Chr1:136394081-136459249 bp, + strand Genetic Position: Chr1, 59.8 cM, cytoband F
• Alliance: Kif14^lag page

Mutation origin

• Strain of Origin: DBA/2NJcl

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A spontaneous G-to-A point mutation in intron 4 disrupts the 3' splice acceptor site for exon 5 by changing it from CAG to CAA. Western blot analysis confirmed the expression of three aberrant proteins and the absence of the wild-type protein in the brain. (J:195809)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kif14 Mutation: 83 strains or lines available

Notes

laggard The laggard phenotype was first observed in F2 progeny of a chimeric mouse derived from 129X1/SvJ RW-4 ES cells, targeted at another locus, and a (C57BL/6NJcl x DBA/2NJcl)F1 female. During the mapping of lag, it was found to have occurred in a DBA/2NJcl-derived genomic region. (J:195809)

References

• Original: J:195809 Fujikura K, et al., Kif14 mutation causes severe brain malformation and hypomyelination. PLoS One. 2013;8(1):e53490
• All: 2 reference(s)