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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zic3tm1.1Smwa
targeted mutation 1.1, Stephanie M Ware
MGI:5476827
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zic3tm1.1Smwa/Y
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S7/SvEvBrd MGI:5476840
cn2
 		Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0 		involves: C3H * C57BL/6 MGI:5476844
cn3
 		Zic3tm1.1Smwa/Y
Tg(Nodal-cre)16Hmd/0 		involves: C57BL/6 MGI:5476845
cn4
 		Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: C57BL/6 * CBA MGI:5476839
cn5
 		Zic3tm1.1Smwa/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:5476842
cn6
 		Zic3tm1.1Smwa/Y
Tg(Myh7-cre)1Jmk/0 		Not Specified MGI:5476843
cn7
 		Zic3tm1.1Smwa/Y
Tg(Mef2c-cre)#Blk/0 		Not Specified MGI:5476841


Genotype
MGI:5476840
cn1
Allelic
Composition		 Zic3tm1.1Smwa/Y
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194989 )
• viable with no cardiac looping defects detected




Genotype
MGI:5476844
cn2
Allelic
Composition		 Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation (1 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal primitive node morphology ( J:194989 )
• similar to germ line null mice

cardiovascular system
abnormal heart looping ( J:194989 )
• defects in looping similar to those in germ line null mice are seen at E10.5 and E13.5




Genotype
MGI:5476845
cn3
Allelic
Composition		 Zic3tm1.1Smwa/Y
Tg(Nodal-cre)16Hmd/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nodal-cre)16Hmd mutation (1 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5476839
cn4
Allelic
Composition		 Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal gastrulation ( J:194989 )
• gastrulation defects
abnormal neural tube morphology ( J:194989 )
• neural tube defects

cardiovascular system
abnormal heart morphology ( J:194989 )
• heart defects

nervous system
abnormal neural tube morphology ( J:194989 )
• neural tube defects




Genotype
MGI:5476842
cn5
Allelic
Composition		 Zic3tm1.1Smwa/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194989 )
• viable with no cardiac looping defects detected




Genotype
MGI:5476843
cn6
Allelic
Composition		 Zic3tm1.1Smwa/Y
Tg(Myh7-cre)1Jmk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh7-cre)1Jmk mutation (0 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194989 )
• viable with no cardiac looping defects detected




Genotype
MGI:5476841
cn7
Allelic
Composition		 Zic3tm1.1Smwa/Y
Tg(Mef2c-cre)#Blk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mef2c-cre)#Blk mutation (0 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:194989 )
• viable with no cardiac looping defects detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory