All Phenotypes Cd3e<tm1.1Geno> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno	involves: C57BL/6	MGI:5474200
cx2	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6	MGI:5474202
cx3	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5474203
cx4	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcrAND)53Hed/0	involves: C57BL/6 * SJL	MGI:5474204

Allelic Composition	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1.1Geno mutation (0 available); any Cd3e mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:192604 )

• partial arrest at the DN3 stage

increased DN3 thymocyte number ( J:192604 )

abnormal double-positive T cell morphology ( J:192604 )

• increase in TCR expression in double positive thymocytes

abnormal T cell number ( J:192604 )

• accumulation of DP2 thymocytes and decrease in the number of DP1 cells, but no change in the absolute number of thymocytes

hematopoietic system

abnormal T cell differentiation ( J:192604 )

• partial arrest at the DN3 stage

abnormal double-positive T cell morphology ( J:192604 )

• increase in TCR expression in double positive thymocytes

abnormal T cell number ( J:192604 )

• accumulation of DP2 thymocytes and decrease in the number of DP1 cells, but no change in the absolute number of thymocytes

increased DN3 thymocyte number ( J:192604 )

endocrine/exocrine glands

increased DN3 thymocyte number ( J:192604 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

abnormal T cell differentiation ( J:192604 )

• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint

• thymocytes accumulate at the DP3 stage

• partial arrest at the DN3 stage

increased DN3 thymocyte number ( J:192604 )

abnormal positive T cell selection ( J:192604 )

• expression analysis indicates a defect in positive selection

decreased double-positive T cell number ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8

decreased T cell number ( J:192604 )

• decrease in the absolute number of thymocytes

hematopoietic system

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

abnormal T cell differentiation ( J:192604 )

• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint

• thymocytes accumulate at the DP3 stage

• partial arrest at the DN3 stage

increased DN3 thymocyte number ( J:192604 )

abnormal positive T cell selection ( J:192604 )

• expression analysis indicates a defect in positive selection

decreased T cell number ( J:192604 )

• decrease in the absolute number of thymocytes

decreased double-positive T cell number ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8

endocrine/exocrine glands

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

increased DN3 thymocyte number ( J:192604 )

Allelic Composition	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1.1Geno mutation (0 available); any Cd3e mutation (47 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased DN3 thymocyte number ( J:192604 )

abnormal negative T cell selection ( J:192604 )

• defects are detected in males

abnormal positive T cell selection ( J:192604 )

• defects are detected in females

hematopoietic system

increased DN3 thymocyte number ( J:192604 )

abnormal negative T cell selection ( J:192604 )

• defects are detected in males

abnormal positive T cell selection ( J:192604 )

• defects are detected in females

endocrine/exocrine glands

increased DN3 thymocyte number ( J:192604 )

Allelic Composition	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcrAND)53Hed/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1.1Geno mutation (0 available); any Cd3e mutation (47 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased DN3 thymocyte number ( J:192604 )

abnormal CD4-positive T cell differentiation ( J:192604 )

• decrease in the formation of CD4 single positive thymocytes

abnormal positive T cell selection ( J:192604 )

hematopoietic system

increased DN3 thymocyte number ( J:192604 )

abnormal CD4-positive T cell differentiation ( J:192604 )

• decrease in the formation of CD4 single positive thymocytes

abnormal positive T cell selection ( J:192604 )

endocrine/exocrine glands

increased DN3 thymocyte number ( J:192604 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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