All Phenotypes Plvap<tm1.1Rvst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plvap^tm1.1Rvst
targeted mutation 1.1, Radu V Stan
MGI:5473517

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe/0	B6.Cg-Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe	MGI:5473520
cn2	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Tek-cre)12Flv/0	B6.Cg-Plvap^tm1.1Rvst Tg(Tek-cre)12Flv	MGI:5473522
cn3	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe/0	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:5473519
cn4	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Tek-cre)12Flv/0	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5473521
cn5	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(VAV1-cre)1Graf/0	involves: 129S4/SvJae * C57BL/6	MGI:5473523

Allelic Composition	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe/0
Genetic Background	B6.Cg-Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvap^tm1.1Rvst mutation (1 available); any Plvap mutation (47 available)
Tg(Cdh5-cre)1Spe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:191046 )

• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age

Allelic Composition	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Tek-cre)12Flv/0
Genetic Background	B6.Cg-Plvap^tm1.1Rvst Tg(Tek-cre)12Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvap^tm1.1Rvst mutation (1 available); any Plvap mutation (47 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:191046 )

• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 3-4 months of age

Allelic Composition	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Cdh5-cre)1Spe/0
Genetic Background	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvap^tm1.1Rvst mutation (1 available); any Plvap mutation (47 available)
Tg(Cdh5-cre)1Spe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:191046 )

• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age

cardiovascular system

abnormal capillary morphology ( J:191046 )

• lack diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals

increased vascular permeability ( J:191046 )

• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells

• leakage of Evans Blue dye is highest in the intestine

homeostasis/metabolism

abnormal circulating lipid level ( J:191046 )

decreased circulating HDL cholesterol level ( J:191046 )

• significantly decreased at 4 weeks of age and does not vary much with time

increased circulating cholesterol level ( J:191046 )

• moderate increase at 4 weeks of age that does not vary much with time

increased circulating triglyceride level ( J:191046 )

• plasma levels are increased 30- to 100-fold from 4 to 8 weeks of age

decreased circulating total protein level ( J:191046 )

ascites ( J:191046 )

• fluid contains albumin and beta globins at similar levels to blood plasma but sharply reduced alpha fractions

growth/size/body

postnatal growth retardation ( J:191046 )

distended abdomen ( J:191046 )

• due to accumulation of ascites

adipose tissue

decreased white adipose tissue amount ( J:191046 )

endocrine/exocrine glands

small pancreas ( J:191046 )

Allelic Composition	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvap^tm1.1Rvst mutation (1 available); any Plvap mutation (47 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:191046 )

• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age

cardiovascular system

abnormal capillary morphology ( J:191046 )

• lack diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals

increased vascular permeability ( J:191046 )

• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells

• leakage of Evans Blue dye is highest in the intestine

homeostasis/metabolism

abnormal circulating lipid level ( J:191046 )

decreased circulating HDL cholesterol level ( J:191046 )

• significantly decreased at 4 weeks of age and does not vary much with time

increased circulating cholesterol level ( J:191046 )

• moderate increase at 4 weeks of age that does not vary much with time

increased circulating triglyceride level ( J:191046 )

• plasma levels are increased 30- to 100-fold from 4 to 8 weeks of age

decreased circulating total protein level ( J:191046 )

ascites ( J:191046 )

• fluid contains albumin and beta globins at similar levels to blood plasma but sharply reduced alpha fractions

growth/size/body

postnatal growth retardation ( J:191046 )

distended abdomen ( J:191046 )

• due to accumulation of ascites

adipose tissue

decreased white adipose tissue amount ( J:191046 )

endocrine/exocrine glands

small pancreas ( J:191046 )

Allelic Composition	Plvap^tm1.1Rvst/Plvap^tm1.1Rvst Tg(VAV1-cre)1Graf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvap^tm1.1Rvst mutation (1 available); any Plvap mutation (47 available)
Tg(VAV1-cre)1Graf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:191046 )

N	• no mortality is seen

cardiovascular system

cardiovascular system phenotype ( J:191046 )

N	• diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals are similar to controls

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