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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sp2tm1.1Htg
targeted mutation 1.1, H Troy Ghashghaei
MGI:5471237
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sp2tm1.1Htg/Sp2tm1.1Htg involves: 129 MGI:5471310
cn2
 		Sp2tm1.1Htg/Sp2tm1.1Htg
Tg(Nes-cre)1Kln/0 		involves: 129 * C57BL/6 * SJL MGI:5471309
cn3
 		Sp2tm1.1Htg/Sp2+
Tg(Nes-cre)1Kln/0 		involves: 129 * C57BL/6 * SJL MGI:5471311
cn4
 		Sp2tm1.1Htg/Sp2tm1.1Htg
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas MGI:5471312


Genotype
MGI:5471310
cn1
Allelic
Composition		 Sp2tm1.1Htg/Sp2tm1.1Htg
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp2tm1.1Htg mutation (0 available); any Sp2 mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:194076 )
• ventricular and subventricular zones of embryonic cortical slices electroporated with a cre-expressing vector exhibit an increase in M-phase cells compared with controls




Genotype
MGI:5471309
cn2
Allelic
Composition		 Sp2tm1.1Htg/Sp2tm1.1Htg
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp2tm1.1Htg mutation (0 available); any Sp2 mutation (151 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194076 )
• many mice die between 2 and 5 weeks after birth with few surviving into adulthood
postnatal lethality, incomplete penetrance ( J:194076 )
• many mice die between 2 and 5 weeks after birth with few surviving into adulthood

nervous system
abnormal neuron differentiation ( J:194076 )
• severely disrupted neuronal and glial differentiation
decreased neuronal precursor proliferation ( J:194076 )
• reduced proliferation of neural stem and neural progenitor cells in the subependymal zone and rostral migratory stream
abnormal rostral migratory stream morphology ( J:194076 )
• enlarged due to increased neuroblasts
hydrocephaly ( J:194076 )
• mild in some mice at P21
abnormal cerebral hemisphere morphology ( J:194076 )
• reduced volume at P21
decreased hippocampus volume ( J:194076 )
• reduced volume at P21
small olfactory bulb ( J:194076 )
• reduced volume at P21

growth/size/body
decreased body size ( J:194076 )
• at P7 and P21
postnatal growth retardation ( J:194076 )
• at P7 and P21

cellular
abnormal cell cycle ( J:194076 )
• increased M-phase of neural stem and neural progenitor cells in the subependymal zone and rostral migratory stream of postnatal mice
• shortened G2-M transition in neural stem and neural progenitor cells
• partial arrest in G2 and M phase in neural stem and neural progenitor cells
• reduced proportion of neural stem and neural progenitor cells in G1/G0
• however, S phase duration is normal
abnormal neuron differentiation ( J:194076 )
• severely disrupted neuronal and glial differentiation
decreased neuronal precursor proliferation ( J:194076 )
• reduced proliferation of neural stem and neural progenitor cells in the subependymal zone and rostral migratory stream




Genotype
MGI:5471311
cn3
Allelic
Composition		 Sp2tm1.1Htg/Sp2+
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp2tm1.1Htg mutation (0 available); any Sp2 mutation (151 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuronal precursor proliferation ( J:194076 )
• reduced proliferation of neural stem and neural progenitor cells in the subependymal zone and rostral migratory stream
abnormal rostral migratory stream morphology ( J:194076 )
• enlarged due to increased neuroblasts
abnormal cerebral hemisphere morphology ( J:194076 )
• reduced volume at P21
decreased hippocampus volume ( J:194076 )
• reduced volume at P21
small olfactory bulb ( J:194076 )
• reduced volume at P21

growth/size/body
decreased body size ( J:194076 )
• at P7 and P21
postnatal growth retardation ( J:194076 )
• at P7 and P21

cellular
decreased neuronal precursor proliferation ( J:194076 )
• reduced proliferation of neural stem and neural progenitor cells in the subependymal zone and rostral migratory stream




Genotype
MGI:5471312
cn4
Allelic
Composition		 Sp2tm1.1Htg/Sp2tm1.1Htg
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Sp2tm1.1Htg mutation (0 available); any Sp2 mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:194076 )
• fewer than expected mice are recovered at birth

nervous system
abnormal neuron differentiation ( J:194076 )
• severely disrupted neuronal and glial differentiation
abnormal cortical plate morphology ( J:194076 )
• increased density at E14.5

cellular
abnormal neuron differentiation ( J:194076 )
• severely disrupted neuronal and glial differentiation




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory