Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation
(0 available);
any
Pfn1 mutation
(10 available)
|
|
|
normal phenotype
|
• mice are viable and fertile
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation
(0 available);
any
Pfn1 mutation
(10 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
|
|
|
cellular
|
• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells
|
cardiovascular system
|
• angiogenesis after ischemia or skin punch is impaired
• however, mice exhibit normal developmental angiogenesis
|
|
• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells
|
|
• after skin punch, mice exhibit fewer microvessels within the healing wound and larger blood vessels in the region surrounding the injury compared with control mice
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation
(0 available);
any
Pfn1 mutation
(10 available)
Tg(Cdh5-cre/ERT2)1Rha mutation
(3 available)
|
|
|
cardiovascular system
|
• after ischemia, tamoxifen-treated mice exhibit impaired angiogenesis and reduced perfusion compared with control mice
|