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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scyl1tm1Spel
targeted mutation 1, Stephane Pelletier
MGI:5469959
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Scyl1tm1Spel/Scyl1tm1Spel
Tg(Ckmm-cre)5Khn/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5469974
cn2
 		Scyl1tm1Spel/Scyl1tm1Spel
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:5469975


Genotype
MGI:5469974
cn1
Allelic
Composition		 Scyl1tm1Spel/Scyl1tm1Spel
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl1tm1Spel mutation (0 available); any Scyl1 mutation (21 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:192445 )
N
• mice exhibit normal gait and motor function

muscle
muscle phenotype ( J:192445 )
N
• mice exhibit normal gait and motor function

nervous system
nervous system phenotype ( J:192445 )
N
• mice exhibit nor signs of neuroinflammation or neurodegeneration




Genotype
MGI:5469975
cn2
Allelic
Composition		 Scyl1tm1Spel/Scyl1tm1Spel
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl1tm1Spel mutation (0 available); any Scyl1 mutation (21 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:192445 )
N
• unlike Scyl1tm1.1Spel homozygotes, mice do not develop tremors and the majority do not become paralyzed
abnormal motor capabilities/coordination/movement ( J:192445 )
• motor dysfunctions develop more slowly and are not as severe as in Scyl1tm1.1Spel homozygotes
abnormal locomotor coordination ( J:192445 )
• posterior waddle by 8 weeks
abnormal gait ( J:192445 )
• by 8 weeks

muscle
muscle phenotype ( J:192445 )
N
• unlike Scyl1tm1.1Spel homozygotes, mice do not develop massive muscle wasting

nervous system

growth/size/body
decreased body weight ( J:192445 )
postnatal growth retardation ( J:192445 )

skeleton
skeleton phenotype ( J:192445 )
N
• unlike Scyl1tm1.1Spel homozygotes, mice do not develop flattening of the pelvis

cardiovascular system

hematopoietic system

immune system

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory