Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation
(0 available);
any
Gfi1 mutation
(31 available)
|
|
|
hematopoietic system
|
N |
• mice exhibit normal lymphoid differentiation in the bone marrow, spleen and thymus and normal numbers of hematopoietic stem cells
|
|
|
• increased granulomonocytic progenitors with a higher proportion in S/G2/M phase
|
|
|
• with a tendency towards lower numbers of granulocytes
|
cellular
|
|
• a higher proportion of granulomonocytic progenitors are undergoing cell cycling compared with wild-type mice or Gfi1tm6.1(GFI1)Tmo homozygotes
|
immune system
|
|
• with a tendency towards lower numbers of granulocytes
|
Allelic
Composition |
Gfi1tm5.1(GFI1*)Tmo/Gfi1+
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation
(0 available);
any
Gfi1 mutation
(31 available)
|
|
|
hematopoietic system
|
|
• proliferative expansion of granulomonocytic progenitors
|
cellular
|
|
• proliferative expansion of granulomonocytic progenitors
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation
(0 available);
any
Gfi1 mutation
(31 available)
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
|
|
mortality/aging
|
|
• of all pIpC-treated mice faster than control mice
|
hematopoietic system
|
|
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice
|
immune system
|
|
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation
(0 available);
any
Gfi1 mutation
(31 available)
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
|
|
mortality/aging
|
|
• of all pIpC-treated mice faster than control mice
|
hematopoietic system
|
|
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice
|
immune system
|
|
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice
|
Analysis Tools