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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmintm1.2Jhh
targeted mutation 1.2, Jorg Heierhorst
MGI:5463937
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5463974
cn2
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S1/Sv * BALB/c * C57BL/6 MGI:5463975
cn3
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 MGI:5463972
cn4
 		Atmintm1.2Jhh/Atmintm1.2Jhh
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5463971


Genotype
MGI:5463974
cn1
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:191832 )
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
decreased immature B cell number ( J:191832 )
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
decreased B cell number ( J:191832 )
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
decreased immature B cell number ( J:191832 )
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:5463975
cn2
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (32 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:191832 )
N
• B cell development is rescued compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased B cell number ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased immature B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased pre-B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased B cell number ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased immature B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased pre-B cell number ( J:191832 )
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

growth/size/body
enlarged spleen ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
increased spleen weight ( J:191832 )
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:5463972
cn3
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice

immune system
abnormal B cell differentiation ( J:191832 )
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
decreased immature B cell number ( J:191832 )
• more than 7-fold in the bone marrow
decreased mature B cell number ( J:191832 )
• more than 7-fold in the spleen
decreased pre-B cell number ( J:191832 )
• 3-fold in the bone marrow
small spleen ( J:191832 )
• 2-fold
abnormal B cell physiology ( J:191832 )
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells

hematopoietic system
abnormal B cell differentiation ( J:191832 )
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
decreased immature B cell number ( J:191832 )
• more than 7-fold in the bone marrow
decreased mature B cell number ( J:191832 )
• more than 7-fold in the spleen
decreased pre-B cell number ( J:191832 )
• 3-fold in the bone marrow
small spleen ( J:191832 )
• 2-fold
abnormal B cell physiology ( J:191832 )
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells




Genotype
MGI:5463971
cn4
Allelic
Composition		 Atmintm1.2Jhh/Atmintm1.2Jhh
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:191832 )
N
• pIpC-treated mice exhibit normal T cell development
decreased lymphocyte cell number ( J:191832 )
• 2-fold in pIpC-treated mice
decreased B cell number ( J:191832 )
• in pIpC-treated mice
decreased mature B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice
• 2-fold in the spleen of pIpC-treated mice
decreased pre-B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice

hematopoietic system
decreased erythrocyte cell number ( J:191832 )
• modest in pIpC-treated mice
decreased lymphocyte cell number ( J:191832 )
• 2-fold in pIpC-treated mice
decreased B cell number ( J:191832 )
• in pIpC-treated mice
decreased mature B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice
• 2-fold in the spleen of pIpC-treated mice
decreased pre-B cell number ( J:191832 )
• in the bone marrow of pIpC-treated mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory