Phenotypes associated with this allele

• Allele Symbol: Calca^{tm1.1(cre/ERT2)Ptch}
• Allele Name: targeted mutation 1.1, Pao-Tien Chuang
• Allele ID: MGI:5460801
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Calca^tm1.1(cre/ERT2)Ptch/Calca^+ Trp53^tm1Brn/Trp53^tm1Brn Rb1^tm2Brn/Rb1^tm2Brn Pten^tm1Hwu/Pten^tm1Hwu	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N	MGI:5460854
cn2	Calca^tm1.1(cre/ERT2)Ptch/Calca^+ Trp53^tm1Brn/Trp53^tm1Brn Rb1^tm2Brn/Rb1^tm2Brn	involves: 129 * 129P2/OlaHsd * FVB/N	MGI:5460840
cn3	Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Calca^tm1.1(cre/ERT2)Ptch/Calca^+	involves: 129P2/OlaHsd * 129S/SvEv	MGI:5460837

Genotype
MGI:5460854

cn1

• Allelic Composition: Calca^{tm1.1(cre/ERT2)Ptch}/Calca⁺; Trp53^tm1Brn/Trp53^tm1Brn; Rb1^tm2Brn/Rb1^tm2Brn; Pten^tm1Hwu/Pten^tm1Hwu
• Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:190366 )

• death within 3 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased metastatic potential ( J:190366 )

• increased invasiveness at 2.5 months after tamoxifen treatment

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Genotype
MGI:5460840

cn2

• Allelic Composition: Calca^{tm1.1(cre/ERT2)Ptch}/Calca⁺; Trp53^tm1Brn/Trp53^tm1Brn; Rb1^tm2Brn/Rb1^tm2Brn
• Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

mortality/aging

postnatal lethality ( J:190366 )

• death within 6-7 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• pulmonary neuroendocrine cells hyperplasia 5-6 months after tamoxifen treatment in 16 of 32 mice examined

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Genotype
MGI:5460837

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Calca^{tm1.1(cre/ERT2)Ptch}/Calca⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

respiratory system

abnormal club cell morphology ( J:190366 )

• clara cell numbers recover after tamoxifen and/or naphthalene lung injury regardless of presence or absence of pulmonary neuroendocrine cells

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• pulmonary neuroendocrine cells ablated by tamoxifen treatment are not replaced at 1, 6, 10, and 12 months after treatment

• naphthalene lung injury fails to induce restoration of this cell type