Phenotypes associated with this allele

• Allele Symbol: Nabp2^tm1.2Nfel
• Allele Name: targeted mutation 1.2, Niklas Feldhahn
• Allele ID: MGI:5448642
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nabp2^tm1.2Nfel/Nabp2^tm1.2Nfel	involves: C57BL/6 * FVB/N * SJL	MGI:5448646
cn2	Nabp2^tm1.1Nfel/Nabp2^tm1.2Nfel Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5448645
cx3	Nabp2^tm1.2Nfel/Nabp2^tm1.2Nfel Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL	MGI:5448647

Genotype
MGI:5448646

hm1

• Allelic Composition: Nabp2^tm1.2Nfel/Nabp2^tm1.2Nfel
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:190019 )

• despite normal numbers at E18.5, no viable mice are present at P0

skeleton

abnormal skeleton morphology ( J:190019 )

abnormal cranium morphology ( J:190019 )

mandible hypoplasia ( J:190019 )

abnormal deltoid tuberosity morphology ( J:190019 )

• missing or rudimentary in the region of the forelimbs

absent deltoid tuberosity ( J:190019 )

abnormal scapular spine morphology ( J:190019 )

• missing or rudimentary in the region of the forelimbs

abnormal rib development ( J:190019 )

• mice exhibit loss or rudimentary ossified segments compared with control mice

small thoracic cage ( J:190019 )

abnormal bone structure ( J:190019 )

• thin and porous

decreased bone volume ( J:190019 )

• in the femur

abnormal cartilage development ( J:190019 )

• defective pre-cartilage mesenchymal condensation at E12.5

limbs/digits/tail

hindlimb oligodactyly ( J:190019 )

• missing digits in the hindlimb

abnormal deltoid tuberosity morphology ( J:190019 )

• missing or rudimentary in the region of the forelimbs

absent deltoid tuberosity ( J:190019 )

abnormal limb development ( J:190019 )

• rudimentary hindlimb at E18.5

cellular

increased embryonic tissue cell apoptosis ( J:190019 )

• at E12.5 in the developing ribs, hindlimb bud and branchial arches

• however, genomic stability in mouse embryonic fibroblasts

chromosomal instability ( J:190019 )

• increased genomic instability at E12.5

growth/size/body

cleft palate ( J:190019 )

fetal growth retardation ( J:190019 )

• at E18.5

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:190019 )

• rudimentary

craniofacial

abnormal cranium morphology ( J:190019 )

mandible hypoplasia ( J:190019 )

cleft palate ( J:190019 )

digestive/alimentary system

cleft palate ( J:190019 )

embryo

increased embryonic tissue cell apoptosis ( J:190019 )

• at E12.5 in the developing ribs, hindlimb bud and branchial arches

• however, genomic stability in mouse embryonic fibroblasts

Genotype
MGI:5448645

cn2

• Allelic Composition: Nabp2^tm1.1Nfel/Nabp2^tm1.2Nfel; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

immune system

immune system phenotype ( J:190019 )

N • mice exhibit normal B and T cell development, immunoglobulin class-switch recombination and genomic stability in dividing B lymphocytes

Genotype
MGI:5448647

cx3

• Allelic Composition: Nabp2^tm1.2Nfel/Nabp2^tm1.2Nfel; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

mortality/aging

mortality/aging ( J:190019 )

N • mice are viable and birth and survive up to 24 hours

postnatal lethality, complete penetrance ( J:190019 )

• mice die after 24 hours of birth

skeleton

abnormal cranium morphology ( J:190019 )

abnormal thoracic cage morphology ( J:190019 )

• thoracic rib cage defects are partially rescued

craniofacial

abnormal cranium morphology ( J:190019 )

cleft palate ( J:190019 )

limbs/digits/tail

abnormal limb development ( J:190019 )

• fore- and hindlimb defects are partially rescued

digestive/alimentary system

cleft palate ( J:190019 )

growth/size/body

cleft palate ( J:190019 )